{"product_id":"9780306460425","title":"NATO Science Series A:: Oxygen Radical Effects, Cellular Protection, and Biological Consequences","description":"\u003ch1\u003eNATO Science Series A:: Oxygen Radical Effects, Cellular Protection, and Biological Consequences\u003c\/h1\u003e \u003ch2\u003eDizdaroglu, Miral; Karakaya, Ali Esat\u003c\/h2\u003e \u003cp\u003eDamage to DNA by both exogenous and endogenous sources is  increasingly regarded as highly important in the initiation and  progression of cancer and in the occurance of other pathological  events. DNA damage caused by reactive oxygen-derived species, also  called oxidative DNA damage, is most the frequent type encountered by  aerobic cells. Mechanistic studies of carcinogenesis indicate an  important role of this type of damage to DNA. There is also strong  evidence to support the role of oxidative DNA damage in the aging  process. DNA damage is opposed \u003cem\u003ein vivo\u003c\/em\u003e by repair systems. If not  repaired, DNA damage may lead to detrimental biological consequences.  Therefore, the repair of DNA damage is regarded as one of the  essential events in all life forms. In recent years the field of DNA  repair has flourished due to new findings on DNA repair mechanisms and  the molecular basis of cancer. A detailed knowledge of mechanisms of  DNA damage and repair, and how individual repair enzymes function may  lead to manipulation of DNA repair in cells and ultimately to an  increase of the resistence of human cells to DNA-damaging agents. This  volume covers the most recent devlopments in this research field and  contains contributions from scientists working in the fields of  biochemistry, molecular biology, enzymology, biomedical science, and  radiation biology.\u003c\/p\u003e \u003ch3\u003eDetails\u003c\/h3\u003e \u003cp\u003ePublished by: Springer\u003c\/p\u003e \u003cp\u003ePublication Date: 1999-02-28\u003c\/p\u003e \u003cp\u003eFormat: Hardcover\u003c\/p\u003e \u003cp\u003eISBN-13: 9780306460425\u003c\/p\u003e \u003cp\u003eDOI: 10.1007\/978-1-4615-4865-2\u003c\/p\u003e \u003cp\u003eDimensions: 235cm x155cm\u003c\/p\u003e \u003cp\u003ePages: 511\u003c\/p\u003e ","brand":"Springer US","offers":[{"title":"Default Title","offer_id":46311844544652,"sku":"9780306460425","price":197.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0710\/9545\/1788\/files\/9780306460425.jpg?v=1771513010","url":"https:\/\/lateknightbooks.com\/products\/9780306460425","provider":"Late Knight Books and Services, LLC","version":"1.0","type":"link"}