{"product_id":"9780387367439","title":"Cancer Treatment and Research","description":"\u003ch1\u003eCancer Treatment and Research\u003c\/h1\u003e \u003ch2\u003eBentzen, Søren M.; Harari, Paul M.; Mackie, T. Rockwell; Mehta, Minesh P.\u003c\/h2\u003e \u003cp\u003efrom combining radiation with a molecular targeted agent – namely cetuximab, a recombinant mouse\/human chimeric monoclonal antibody against the Epidermal Growth Factor (EGF) receptor [4] Astsaturov, Cohen and Harari present a more indepth review of the biology of the EGF Receptor and its signaling pathway in Chap. 7 as a potential target in combination with fractionated radiotherap y for head and neck squamous cell carcinoma (HNSCC). A flurry of agents are under de velopment for targeting EGFR and in March 2006, the US Food and Drugs Administration approved cetuximab combined with radiation as a primary treatment option for patients with loco-regionally advanced HNSCC in whom chemoradiation therapy is deemed not to be an option. While blocking the EGF pathway during fractionated radiotherapy may seem an obvious strategy [5], the rationale for combining antiangiogenic and antivascular targeting agents with radiation may be less intuitive. However, recent research shows that there are several reasons why this could result in a therapeutic gain in practice. Chapter 8 is a review of this rapidly expanding field by Citrin and Camphausen. Targeted agents combined with radiation may offer new opportunities in the treatment of central nervous system malignancies, a tumor type where the outlook remains poor despite some recent progress [6]. Current attempts to overcome rad- tion resistance in these tumors on the basis of an improved understanding of their molecular biology are the topic of Chap. 9 by Chakravarti and Palanichamy.\u003c\/p\u003e \u003ch3\u003eDetails\u003c\/h3\u003e \u003cp\u003ePublished by: Springer\u003c\/p\u003e \u003cp\u003ePublication Date: 2007-11-15\u003c\/p\u003e \u003cp\u003eFormat: Hardcover\u003c\/p\u003e \u003cp\u003eISBN-13: 9780387367439\u003c\/p\u003e \u003cp\u003eDOI: 10.1007\/978-0-387-36744-6\u003c\/p\u003e \u003cp\u003eDimensions: 235cm x155cm\u003c\/p\u003e \u003cp\u003ePages: 336\u003c\/p\u003e ","brand":"Springer US","offers":[{"title":"Default Title","offer_id":47661443317900,"sku":"9780387367439","price":152.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0710\/9545\/1788\/files\/9780387367439.jpg?v=1776429531","url":"https:\/\/lateknightbooks.com\/products\/9780387367439","provider":"Late Knight Books and Services, LLC","version":"1.0","type":"link"}