{"product_id":"9780470059050","title":"Protein Surface Recognition Approaches for Drug Discovery","description":"\u003ch1\u003eProtein Surface Recognition\u003c\/h1\u003e\u003ch2\u003eApproaches for Drug Discovery\u003c\/h2\u003e\u003ch3\u003eErnest Giralt | Mark Peczuh | Xavier Salvatella\u003c\/h3\u003e\u003cdiv\u003e\u003cb\u003eScience \/ Chemistry \/ Industrial \u0026amp; Technical\u003c\/b\u003e\u003c\/div\u003e\u003cbr\u003e\u003cdiv\u003eA new perspective on the design of molecular therapeutics is emerging. This new strategy emphasizes the rational complementation of functionality along extended patches of a protein surface with the aim of inhibiting protein\/protein interactions. The successful development of compounds able to inhibit these interactions offers a unique chance to selectively intervene in a large number of key cellular processes related to human disease.  \u003cp\u003e\u003ci\u003eProtein Surface Recognition\u003c\/i\u003e presents a detailed treatment of this strategy, with topics including:\u003c\/p\u003e \u003cul\u003e \u003cli\u003ean extended survey of protein-protein interactions that are key players in human disease and biology and the potential for therapeutics derived from this new perspective\u003c\/li\u003e \u003cli\u003ethe fundamental physical issues that surround protein-protein interactions that must be considered when designing ligands for protein surfaces\u003c\/li\u003e \u003cli\u003eexamples of protein surface-small molecule interactions, including treatments of protein-natural product interactions, protein-interface peptides, and rational approaches to protein surface recognition from model to biological systems\u003c\/li\u003e \u003cli\u003ea survey of techniques that will be integral to the discovery of new small molecule protein surface binders, from high throughput synthesis and screening techniques to \u003ci\u003ein silico\u003c\/i\u003e and \u003ci\u003ein vitro\u003c\/i\u003e methods for the discovery of novel protein ligands.\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003e\u003ci\u003eProtein Surface Recognition\u003c\/i\u003e provides an intellectual “tool-kit” for investigators in medicinal and bioorganic chemistry looking to exploit this emerging paradigm in drug discovery.\u003c\/p\u003e\n\u003c\/div\u003e\u003cdiv\u003e  \u003cb\u003eERNEST GIRALT,\u003c\/b\u003e Department of Organic Chemistry, University of Barcelona and Institute for Research in Biomedicine, Barcelona, Spain  \u003cp\u003e\u003cb\u003eMARK PECZUH,\u003c\/b\u003e Department of Chemistry, University of Connecticut, USA\u003c\/p\u003e \u003cp\u003e\u003cb\u003eXAVIER SALVATELLA,\u003c\/b\u003e ICREA and Institute for Research in Biomedicine, Barcelona, Spain\u003c\/p\u003e\n\u003c\/div\u003e\u003cbr\u003e\u003ctable\u003e\n\u003ctr\u003e\n\u003ctd\u003ePublication Date: \u003c\/td\u003e\n\u003ctd\u003e08 December 2010\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePublisher: \u003c\/td\u003e\n\u003ctd\u003eWiley\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eImprint: \u003c\/td\u003e\n\u003ctd\u003eWiley\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eISBN-13: \u003c\/td\u003e\n\u003ctd\u003e9780470059050\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eFormat: \u003c\/td\u003e\n\u003ctd\u003eHardback\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePage Count: \u003c\/td\u003e\n\u003ctd\u003e344\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eWeight (oz): \u003c\/td\u003e\n\u003ctd\u003e27.36\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/table\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":44378773586060,"sku":"9780470059050","price":160.16,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0710\/9545\/1788\/files\/9780470059050_ab32827a-511e-4d9b-abca-c1c05b5c4d84.jpg?v=1780234435","url":"https:\/\/lateknightbooks.com\/products\/9780470059050","provider":"Late Knight Books and Services, LLC","version":"1.0","type":"link"}