{"product_id":"9780470227343","title":"ABC Transporters and Multidrug Resistance","description":"\u003ch3\u003eWiley Series in Drug Discovery and Development\u003c\/h3\u003e\u003ch1\u003eABC Transporters and Multidrug Resistance\u003c\/h1\u003e\u003ch3\u003eAhcène Boumendjel | Jean Boutonnat | Jacques Robert\u003c\/h3\u003e\u003cdiv\u003e\u003cb\u003eMedical \/ Pharmacology\u003c\/b\u003e\u003c\/div\u003e\u003cbr\u003e\u003cdiv\u003e\n\u003cb\u003eA comprehensive review of the most current scientific research on ABC transporters and multidrug resistance\u003c\/b\u003e  \u003cp\u003eATP-binding cassette transporter genes (ABC transporters) are known to play a crucial role in the development of multidrug resistance (MDR). MDR is the ability of pathologic cells, such as tumors, to withstand chemicals designed to target and destroy such cells. In MDR, patients who are on medication eventually develop resistance to not only the drug they are taking, but to several different types of drugs.\u003c\/p\u003e \u003cp\u003e\u003ci\u003eABC Transporters and Multidrug Resistance\u003c\/i\u003e offers an essential resource for pharmaceutical researchers who are working to discover drugs to counteract multidrug resistance in diseases such as cancer. In one comprehensive volume, this book contains a collection of the most current knowledge on the involvement of ABC transporters in drug transport and resistance.\u003c\/p\u003e \u003cp\u003eThis comprehensive volume provides an overview on the description of the structure, the genome, normal tissue expression, physiological aspect, and mechanism of action of the ABC protein. The expert contributors explore the expression, detection, and implications of ABC proteins in hematological malignancies and solid tumors and ABC proteins and pathogenic microorganisms. This volume also explains MDR modulation through inhibition of ABC transporters and the design of inhibitors and mechanism of action. In addition, the book offers essential information on the biological and clinical aspect of multidrug resistance.\u003c\/p\u003e\n\u003c\/div\u003e\u003cdiv\u003e  \u003cb\u003eAhcéne Boumendjel\u003c\/b\u003e is Professor of Medicinal Chemistry at the University of Grenoble School of Pharmacy, France.  \u003cp\u003e\u003cb\u003eJean Boutonnat\u003c\/b\u003e is an Assistant Professor and Hospital Practitioner at the Grenoble Medical School and Université Joseph Fourier of Grenoble, France.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eJacques Robert\u003c\/b\u003e is Professor and Head of the Laboratory of Pharmacology of Anticancer Agents at Institut Bergonié and Université Victor Segalen Bordeaux 2, France.\u003c\/p\u003e\n\u003c\/div\u003e\u003cbr\u003e\u003ctable\u003e\n\u003ctr\u003e\n\u003ctd\u003ePublication Date: \u003c\/td\u003e\n\u003ctd\u003e20 July 2009\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePublisher: \u003c\/td\u003e\n\u003ctd\u003eWiley\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eImprint: \u003c\/td\u003e\n\u003ctd\u003eWiley\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eISBN-13: \u003c\/td\u003e\n\u003ctd\u003e9780470227343\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eFormat: \u003c\/td\u003e\n\u003ctd\u003eHardback\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePage Count: \u003c\/td\u003e\n\u003ctd\u003e480\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eWeight (oz): \u003c\/td\u003e\n\u003ctd\u003e27.2\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/table\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":44310764257420,"sku":"9780470227343","price":166.46,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0710\/9545\/1788\/files\/9780470227343_0ba97140-02c1-4d30-b91f-e88e6ddd9d21.jpg?v=1780101790","url":"https:\/\/lateknightbooks.com\/products\/9780470227343","provider":"Late Knight Books and Services, LLC","version":"1.0","type":"link"}