{"product_id":"9780470275009","title":"Drug Design of Zinc-Enzyme Inhibitors Functional, Structural, and Disease Applications","description":"\u003ch3\u003eWiley Series in Drug Discovery and Development\u003c\/h3\u003e\u003ch1\u003eDrug Design of Zinc-Enzyme Inhibitors\u003c\/h1\u003e\u003ch2\u003eFunctional, Structural, and Disease Applications\u003c\/h2\u003e\u003ch3\u003eClaudiu T. Supuran | Jean-Yves Winum | Binghe Wang\u003c\/h3\u003e\u003cdiv\u003e\u003cb\u003eMedical \/ Pharmacology\u003c\/b\u003e\u003c\/div\u003e\u003cbr\u003e\u003cdiv\u003e\n\u003cb\u003eBrings together functional and structural informationrelevant to the design of drugs targeting zinc enzymes\u003c\/b\u003e  \u003cp\u003eThe second most abundant transition element in living organisms, zinc spans all areas of metabolism, with zinc-containing proteins offering both established and potential drug targets. \u003ci\u003eDrug Design of Zinc-Enzyme Inhibitors\u003c\/i\u003e brings together functional and structural information relevant to these zinc-containing targets. With up-to-date overviews of the latest developments field, this unique and comprehensive text enables readers to understand zinc enzymes and evaluate them in a drug design context.\u003c\/p\u003e \u003cp\u003eWith contributions from the leaders of today's research, \u003ci\u003eDrug Design of Zinc-Enzyme Inhibitors\u003c\/i\u003e covers such key topics as:\u003c\/p\u003e \u003cul\u003e \u003cli\u003e \u003cp\u003eMajor drug targets like carbonic anhydrases, matrix metalloproteinases, bacterial proteases, angiotensin-converting enzyme, histone deacetylase, and APOBEC3G\u003c\/p\u003e \u003c\/li\u003e \u003cli\u003e \u003cp\u003eRoles of recently discovered zinc-containing isozymes in cancer, obesity, epilepsy, pain management, malaria, and other conditions\u003c\/p\u003e \u003c\/li\u003e \u003cli\u003e \u003cp\u003eCross reactivity of zinc-enzyme inhibitors and activators\u003c\/p\u003e \u003c\/li\u003e \u003cli\u003e \u003cp\u003eThe extensive use of X-ray crystallography and QSAR studies for understanding zinc-containing proteins\u003c\/p\u003e \u003c\/li\u003e \u003cli\u003e \u003cp\u003eClinical applications\u003c\/p\u003e \u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eAn essential resource for the discovery and development of new drug molecules, \u003ci\u003eDrug Design of Zinc-Enzyme Inhibitors\u003c\/i\u003e gives researchers, professionals, students, and academics the foundation to understand and work with zinc enzyme inhibitors and activators.\u003c\/p\u003e\n\u003c\/div\u003e\u003cdiv\u003e  \u003cb\u003eClaudiu T. Supuran\u003c\/b\u003e is a professor in the Department of Chemistry at the University of Florence, Italy. His main research interests include medicinal chemistry, design of enzyme inhibitors and activators, X-ray crystallography of metallo-enzymes, and metal complexes with biologically active ligands (metal-based drugs). He has published more than 400 original research papers in these fields.  \u003cp\u003e\u003cb\u003eJean-Yves Winum\u003c\/b\u003e is an assistant professor in the Department of Chemistry at the University of Montpellier 2 (Institut des Biomolécules Max Mousseron UMR CNRS 5247), France. His research interests are focused on organic\/medicinal chemistry of metallo-enzyme inhibitors and activators.\u003c\/p\u003e\n\u003c\/div\u003e\u003cbr\u003e\u003ctable\u003e\n\u003ctr\u003e\n\u003ctd\u003ePublication Date: \u003c\/td\u003e\n\u003ctd\u003e17 August 2009\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePublisher: \u003c\/td\u003e\n\u003ctd\u003eWiley\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eImprint: \u003c\/td\u003e\n\u003ctd\u003eWiley\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eISBN-13: \u003c\/td\u003e\n\u003ctd\u003e9780470275009\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eFormat: \u003c\/td\u003e\n\u003ctd\u003eHardback\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePage Count: \u003c\/td\u003e\n\u003ctd\u003e1056\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eWeight (oz): \u003c\/td\u003e\n\u003ctd\u003e55.68\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/table\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":44381207920780,"sku":"9780470275009","price":257.36,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0710\/9545\/1788\/files\/9780470275009.jpg?v=1780235494","url":"https:\/\/lateknightbooks.com\/products\/9780470275009","provider":"Late Knight Books and Services, LLC","version":"1.0","type":"link"}