{"product_id":"9780470519745","title":"The Chemical Biology of Nucleic Acids","description":"\u003ch1\u003eThe Chemical Biology of Nucleic Acids\u003c\/h1\u003e\u003ch3\u003eGünter Mayer\u003c\/h3\u003e\u003cdiv\u003e\u003cb\u003eScience \/ Life Sciences \/ Biochemistry\u003c\/b\u003e\u003c\/div\u003e\u003cbr\u003e\u003cdiv\u003eWith extensive coverage of synthesis techniques and applications, this text describes chemical biology techniques which have gained significant impetus during the last five years. It focuses on the methods for obtaining modified and native nucleic acids, and their biological applications. Topics covered include:  \u003cul\u003e \u003cli\u003e\u003ca id=\"_Toc223430553\" name=\"_Toc223430553\"\u003echemical synthesis of modified RNA\u003c\/a\u003e\u003c\/li\u003e \u003cli\u003eexpansion of the genetic alphabet in nucleic acids by creating new base pairs\u003c\/li\u003e \u003cli\u003echemical biology of DNA replication: probing DNA polymerase selectivity mechanisms with modified nucleotides\u003c\/li\u003e \u003cli\u003enucleic-acid-templated chemistry\u003c\/li\u003e \u003cli\u003echemical biology of peptide nucleic acids (PNA)\u003c\/li\u003e \u003cli\u003ethe interactions of small molecules with DNA and RNA\u003c\/li\u003e \u003cli\u003ethe architectural modules of folded RNAs\u003c\/li\u003e \u003cli\u003egenesis and biological applications of locked nucleic acid (LNA)\u003c\/li\u003e \u003cli\u003esmall non-coding RNA in bacteria\u003c\/li\u003e \u003cli\u003emicroRNA-guided gene silencing\u003c\/li\u003e \u003cli\u003enucleic acids based therapies\u003c\/li\u003e \u003cli\u003einnate immune recognition of nucleic acid\u003c\/li\u003e \u003cli\u003elight-responsive nucleic acids for the spatiotemporal control of biological processes\u003c\/li\u003e \u003cli\u003eDNA methylation\u003c\/li\u003e \u003cli\u003eframeworks for programming RNA devices\u003c\/li\u003e \u003cli\u003eRNA as a catalyst: The Diels-Alderase-Ribozyme\u003c\/li\u003e \u003cli\u003eevolving an understanding of RNA function by \u003ci\u003ein vitro\u003c\/i\u003e approaches\u003c\/li\u003e \u003cli\u003ethe chemical biology of aptamers: synthesis and applications\u003c\/li\u003e \u003cli\u003enucleic acids as detection tools\u003c\/li\u003e \u003cli\u003ebacterial riboswitch discovery and analysis\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003e\u003ci\u003eThe Chemical Biology of Nucleic Acids\u003c\/i\u003e is an essential compendium of the synthesis of nucleic acids and their biological applications for bioorganic chemists, chemical biologists, medicinal chemists, cell biologists, and molecular biologists.\u003c\/p\u003e\n\u003c\/div\u003e\u003cdiv\u003e \u003cp\u003e\u003cb\u003eGünter Mayer\u003c\/b\u003e, Assistant Professor, LIMES Prog. Unit Chemical Biology and Medicinal Chemistry, Kekulé-Institute for Organic Chemistry and Biochemistry, University of Bonn, Germany\u003cbr\u003eProfessor Mayer's research involves molecular diversity applied to elucidate the conformation, function and identity of biomolecules. He is a co-founder of NascaCell Technologies AG, a leading service provider of innovative biomolecules, where he headed the combinatorial biotechnology department. He has published papers in leading journals such as \u003ci\u003eNature, Angewandte Chemie\u003c\/i\u003e and \u003ci\u003eJournal of the American Chemical Society\u003c\/i\u003e.\u003c\/p\u003e\n\u003c\/div\u003e\u003cbr\u003e\u003ctable\u003e\n\u003ctr\u003e\n\u003ctd\u003ePublication Date: \u003c\/td\u003e\n\u003ctd\u003e20 July 2010\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePublisher: \u003c\/td\u003e\n\u003ctd\u003eWiley\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eImprint: \u003c\/td\u003e\n\u003ctd\u003eWiley\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eISBN-13: \u003c\/td\u003e\n\u003ctd\u003e9780470519745\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eFormat: \u003c\/td\u003e\n\u003ctd\u003eHardback\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePage Count: \u003c\/td\u003e\n\u003ctd\u003e480\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eWeight (oz): \u003c\/td\u003e\n\u003ctd\u003e39.0\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/table\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":44384860373132,"sku":"9780470519745","price":188.06,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0710\/9545\/1788\/files\/9780470519745.jpg?v=1780175421","url":"https:\/\/lateknightbooks.com\/products\/9780470519745","provider":"Late Knight Books and Services, LLC","version":"1.0","type":"link"}