{"product_id":"9780470998090","title":"Quantitative Modeling in Toxicology","description":"\u003ch1\u003eQuantitative Modeling in Toxicology\u003c\/h1\u003e\u003ch2\u003e\u003c\/h2\u003e\u003cp\u003e\u003cstrong\u003eContributors:\u003c\/strong\u003e Krishnan, Kannan; Andersen, Melvin E.\u003c\/p\u003e\u003cp\u003eGovernments around the world are passing laws requiring industry to assess the toxicity of the chemicals and products they produce, but to do so while reducing, refining, or even replacing testing on animals. To meet these requirements, experimental toxicologists and risk assessors are adopting quantitative approaches and computer simulations to study the biological fate and effects of chemicals and drugs.  \u003c\/p\u003e\u003cp\u003eIn \u003ci\u003eQuantitative Modeling in Toxicology\u003c\/i\u003e leading experts outline the current state of knowledge on the modeling of dose, tissue interactions and tissue responses. Each chapter describes the mathematical foundation, parameter estimation, challenges and perspectives for development, along with the presentation of a modeling template. Additionally, tools and approaches for conducting uncertainty, sensitivity and variability analyses in these models are described.  Topics covered include:\u003c\/p\u003e \u003cul\u003e \u003cli\u003ethe quantitative models of pharmacokinetics of individual chemicals and mixtures\u003c\/li\u003e \u003cli\u003emodels for toxicant-target tissue interaction. \u003c\/li\u003e \u003cli\u003emodels for cellular, organ, and organism responses.\u003c\/li\u003e \u003cli\u003eapproaches, tools and challenges for model application and evaluation\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eA website containing computer codes accompanies the book to help the reader reconstruct the models described and discussed in the various chapters.\u003c\/p\u003e \u003cp\u003e\u003ci\u003eQuantitative Modeling in Toxicology\u003c\/i\u003e serves as an essential reference source and tool box for risk assessors and researchers and students in toxicology, public health, pharmacology, and human toxicology interested in developing quantitative models for a better understanding of dose-response relationships.\u003c\/p\u003e\u003ch3\u003eBook Details\u003c\/h3\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003ePublisher:\u003c\/strong\u003e Wiley\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePublication Date:\u003c\/strong\u003e 2010-05-03\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Hardcover\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eISBN-13:\u003c\/strong\u003e 9780470998090\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePages:\u003c\/strong\u003e 504\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":44379038613644,"sku":"9780470998090","price":161.95,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0710\/9545\/1788\/files\/9780470998090_7d73a576-3411-422d-b929-9192bf475958.jpg?v=1768917439","url":"https:\/\/lateknightbooks.com\/products\/9780470998090","provider":"Late Knight Books and Services, LLC","version":"1.0","type":"link"}