{"product_id":"9780471653967","title":"The Theory of Response-Adaptive Randomization in Clinical Trials","description":"\u003ch3\u003eWiley Series in Probability and Statistics\u003c\/h3\u003e\u003ch1\u003eThe Theory of Response-Adaptive Randomization in Clinical Trials\u003c\/h1\u003e\u003ch3\u003eFeifang Hu | William F. Rosenberger\u003c\/h3\u003e\u003cdiv\u003e\u003cb\u003eMathematics \/ Probability \u0026amp; Statistics \/ General\u003c\/b\u003e\u003c\/div\u003e\u003cbr\u003e\u003cdiv\u003e\n\u003cb\u003ePresents a firm mathematical basis for the use of response-adaptive randomization procedures in practice\u003c\/b\u003e  \u003cp\u003e\u003ci\u003eThe Theory of Response-Adaptive Randomization in Clinical Trials\u003c\/i\u003e is the result of the authors' ten-year collaboration as well as their collaborations with other researchers in investigating the important questions regarding response-adaptive randomization in a rigorous mathematical framework. Response-adaptive allocation has a long history in biostatistics literature; however, largely due to the disastrous ECMO trial in the early 1980s, there is a general reluctance to use these procedures.\u003c\/p\u003e \u003cp\u003eThis timely book represents a mathematically rigorous subdiscipline of experimental design involving randomization and answers fundamental questions, including:\u003c\/p\u003e \u003cul\u003e \u003cli\u003eHow does response-adaptive randomization affect power?\u003c\/li\u003e \u003cli\u003eCan standard inferential tests be applied following response-adaptive randomization?\u003c\/li\u003e \u003cli\u003eWhat is the effect of delayed response?\u003c\/li\u003e \u003cli\u003eWhich procedure is most appropriate and how can \"most appropriate\" be quantified?\u003c\/li\u003e \u003cli\u003eHow can heterogeneity of the patient population be incorporated?\u003c\/li\u003e \u003cli\u003eCan response-adaptive randomization be performed with more than two treatments or with continuous responses?\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eThe answers to these questions communicate a thorough understanding of the asymptotic properties of each procedure discussed, including asymptotic normality, consistency, and asymptotic variance of the induced allocation. Topical coverage includes:\u003c\/p\u003e \u003cul\u003e \u003cli\u003eThe relationship between power and response-adaptive randomization\u003c\/li\u003e \u003cli\u003eThe general result for determining asymptotically best procedures\u003c\/li\u003e \u003cli\u003eProcedures based on urn models\u003c\/li\u003e \u003cli\u003eProcedures based on sequential estimation\u003c\/li\u003e \u003cli\u003eImplications for the practice of clinical trials\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eUseful for graduate students in mathematics, statistics, and biostatistics as well as researchers and industrial and academic biostatisticians, this book offers a rigorous treatment of the subject in order to find the optimal procedure to use in practice.\u003c\/p\u003e\n\u003c\/div\u003e\u003cdiv\u003e  \u003cb\u003eFEIFANG HU\u003c\/b\u003e, PhD, is Associate Professor in the Department of Statistics at the University of Virginia. He is the recipient of numerous grants, honors, and awards. His research interests include biostatistics, applied probability and statistical inference, and resampling methods. He has authored over forty refereed articles.  \u003cp\u003e\u003cb\u003eWILLIAM F. ROSENBERGER\u003c\/b\u003e, PhD, is Professor and Chair of the Department of Applied and Engineering Statistics at George Mason University. He received the Association of American Publishers' Professional\/Scholarly Publishing Award in 2002 for his coauthored work, Randomization in Clinical Trials: Theory And Practice (Wiley). A Fellow of the American Statistical Association, he has authored over fifty refereed articles and edited two monographs.\u003c\/p\u003e\n\u003c\/div\u003e\u003cbr\u003e\u003ctable\u003e\n\u003ctr\u003e\n\u003ctd\u003ePublication Date: \u003c\/td\u003e\n\u003ctd\u003e18 August 2006\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePublisher: \u003c\/td\u003e\n\u003ctd\u003eWiley\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eImprint: \u003c\/td\u003e\n\u003ctd\u003eWiley-Interscience\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eISBN-13: \u003c\/td\u003e\n\u003ctd\u003e9780471653967\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eFormat: \u003c\/td\u003e\n\u003ctd\u003eHardback\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePage Count: \u003c\/td\u003e\n\u003ctd\u003e232\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eWeight (oz): \u003c\/td\u003e\n\u003ctd\u003e16.48\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/table\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":44311418503308,"sku":"9780471653967","price":154.76,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0710\/9545\/1788\/files\/9780471653967_2c6f08fe-ff58-4dc6-91d0-fdf5dbd30e27.jpg?v=1780176869","url":"https:\/\/lateknightbooks.com\/products\/9780471653967","provider":"Late Knight Books and Services, LLC","version":"1.0","type":"link"}