{"product_id":"9780792335252","title":"Cancer Treatment and Research","description":"\u003ch1\u003eCancer Treatment and Research\u003c\/h1\u003e \u003ch2\u003eMuggia, Franco M.\u003c\/h2\u003e \u003cp\u003e\u003cem\u003eConcepts, Mechanisms, and New Targets for Chemotherapy\u003c\/em\u003e  describes new interconnections between rationally designed and  empirically discovered compounds. One route that has not been  travelled previously is that of protein kinase C inhibition. This  pathway may be exploited to give potent inhibitors, such as the  bryostatins, now in clinical trial. A summary is given of the current  status of topoisomerase, focusing on recent clinical advances with  camptothecin analogs based on connecting empiricism with concepts of  drug selectivity. \u003cbr\u003e  Modification of existing therapies based on the pursuit of leads  arising from mechanistic studies is also being applied clinically on a  wide scale. Greater understanding should follow from the studies of  reversal of the multidrug resistant phenotype, on the use of  hydroxyurea to reverse resistance mediated by extrachromosomal DNA,  and on various aspects of the fluoropyrimidine pathways. \u003cbr\u003e  Successful applications of chemotherapy to the treatment of specific  diseases include the growing applications of systemic therapy using  various skin malignancies. In prostate cancer, estramustine phosphate  will likely play an expanding role. Taxanes are restructuring  treatment regimens in breast cancer, and high-dose strategies are  described with peripheral blood progenitor autografting in the  treatment of ovarian and breast cancers.\u003c\/p\u003e \u003ch3\u003eDetails\u003c\/h3\u003e \u003cp\u003ePublished by: Springer\u003c\/p\u003e \u003cp\u003ePublication Date: 1995-12-31\u003c\/p\u003e \u003cp\u003eFormat: Hardcover\u003c\/p\u003e \u003cp\u003eISBN-13: 9780792335252\u003c\/p\u003e \u003cp\u003eDOI: 10.1007\/978-1-4615-2007-8\u003c\/p\u003e \u003cp\u003eDimensions: 235cm x155cm\u003c\/p\u003e \u003cp\u003ePages: 237\u003c\/p\u003e ","brand":"Springer US","offers":[{"title":"Default Title","offer_id":46311620247692,"sku":"9780792335252","price":197.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0710\/9545\/1788\/files\/9780792335252.jpg?v=1771508197","url":"https:\/\/lateknightbooks.com\/products\/9780792335252","provider":"Late Knight Books and Services, LLC","version":"1.0","type":"link"}