{"product_id":"9780792370604","title":"Synthesis of β-Lactam Antibiotics: Chemistry, Biocatalysis \u0026 Process Integration","description":"\u003ch1\u003eSynthesis of β-Lactam Antibiotics: Chemistry, Biocatalysis \u0026amp; Process Integration\u003c\/h1\u003e \u003ch2\u003eBruggink, Alle\u003c\/h2\u003e \u003cp\u003ePenicillins and cephalosporins have a long history in combating  bacterial infections. Despite new infectious diseases and occurring  resistance, beta-lactam antibiotics will for many years to come  continue to play a prominent role in our therapeutic arsenal. This  book covers the industrial development of the chemical and biochemical  processes used to manufacture these products, as well as looking ahead  to possible future processes. The interplay between synthetic organic  chemistry with the understanding and application of enzymes, modeling  of fermentation processes and integration through (bio-) chemical  process engineering is illustrated. In-depth scientific approaches to  biocatalysis and biocatalyst development including enzyme kinetics,  enzyme crystal studies and semi-rational enzyme mutations are also  presented. Metabolic pathway analysis and modeling of fermentation  process are treated as well as molecular precision in synthetic  approaches to beta-lactams, their precursors and derivatives. Process  technology studies including new reactor concepts, possible short-cut  routes and improved down-stream-processing methods complete a broad  view on the scope and limitations of the presently developed  industrial processes including an intriguing insight into future  process possibilities. This book represents an excellent case study on  the transformation of traditional, stoïchiometric, organic  synthesis and classical fermentations into modern (bio-) catalysis and  biosynthesis based on insights in metabolic pathways and enzyme  actions.\u003c\/p\u003e \u003ch3\u003eDetails\u003c\/h3\u003e \u003cp\u003ePublished by: Springer\u003c\/p\u003e \u003cp\u003ePublication Date: 2001-06-30\u003c\/p\u003e \u003cp\u003eFormat: Hardcover\u003c\/p\u003e \u003cp\u003eISBN-13: 9780792370604\u003c\/p\u003e \u003cp\u003eDOI: 10.1007\/978-94-010-0850-1\u003c\/p\u003e \u003cp\u003eDimensions: 254cm x178cm\u003c\/p\u003e \u003cp\u003ePages: 324\u003c\/p\u003e ","brand":"Springer Netherlands","offers":[{"title":"Default Title","offer_id":46266207240332,"sku":"9780792370604","price":152.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0710\/9545\/1788\/files\/9780792370604.jpg?v=1770815116","url":"https:\/\/lateknightbooks.com\/products\/9780792370604","provider":"Late Knight Books and Services, LLC","version":"1.0","type":"link"}