{"product_id":"9780792379843","title":"Biochemistry and Genetics of Recq-Helicases","description":"\u003ch1\u003eBiochemistry and Genetics of Recq-Helicases\u003c\/h1\u003e \u003ch2\u003eLombard, David B.\u003c\/h2\u003e \u003cp\u003e\u003cem\u003eBiochemistry And Genetics of RecQ-Helicases\u003c\/em\u003e provides a  background into the role of helicases in general and RecQ helicases  specifically in DNA repair. Helicases- enzymes which break down  hydrogen bonds between nucleic acid strands in a nucleoside  triphosphate-dependent manner-are ubiquitous in biology, participating  in processes as diverse as replication, repair, recombination,  transcription, and translation. The RecQ-family helicases are a group  of helicases which have important roles in the maintenance of genomic  stability in many organisms. In humans, mutations in three RecQ-family  helicases lead to disease. This book thoroughly examines these  helicases. Mutations in the BLM gene lead to Bloom syndrome, a  disorder characterized by a susceptibility to many types of cancer.  Mutations in the WRN gene cause Werner syndrome, a disease which in  some respects resembles premature aging. Finally, mutations in a newly  characterized RecQ-family member, RECQ4, may lead to the very rare  recessive disorder Rothmund-Thomson syndrome, a condition  characterized by developmental abnormalities and some aging-like  manifestations. This book is intended for any researchers invested in  these particular disorders, or with a general interest in DNA.\u003c\/p\u003e \u003ch3\u003eDetails\u003c\/h3\u003e \u003cp\u003ePublished by: Springer\u003c\/p\u003e \u003cp\u003ePublication Date: 2000-11-30\u003c\/p\u003e \u003cp\u003eFormat: Hardcover\u003c\/p\u003e \u003cp\u003eISBN-13: 9780792379843\u003c\/p\u003e \u003cp\u003eDOI: 10.1007\/978-1-4615-1405-3\u003c\/p\u003e \u003cp\u003eDimensions: 235cm x155cm\u003c\/p\u003e \u003cp\u003ePages: 92\u003c\/p\u003e ","brand":"Springer US","offers":[{"title":"Default Title","offer_id":46266226540684,"sku":"9780792379843","price":98.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0710\/9545\/1788\/files\/9780792379843.jpg?v=1770816031","url":"https:\/\/lateknightbooks.com\/products\/9780792379843","provider":"Late Knight Books and Services, LLC","version":"1.0","type":"link"}