{"product_id":"9780792382423","title":"Perspectives in Antisense Science","description":"\u003ch1\u003ePerspectives in Antisense Science\u003c\/h1\u003e \u003ch2\u003eMcCarthy, Margaret M.\u003c\/h2\u003e \u003cp\u003eWhen first introduced, antisense oligonucleotides were hailed  as the long awaited magic bullet that would provide an unprecedented  level of specificity in controlling gene expression. Following this  initial enthusiasm, antisense oligonucleotides have been maligned as  nonspecific, toxic, and essentially useless. However, application of  antisense oligonucleotide technology in the nervous system stands  apart from the use of this technique in peripheral systems, largely  because of its enormous success. The source of this success remains a  matter of some controversy.\u003cbr\u003e  \u003cem\u003eModulating Gene Expression by Antisense Oligonucleotides to  Understand\u003c\/em\u003e \u003cem\u003eNeural Functioning\u003c\/em\u003e addresses the origins of that  controversy and determines whether the nervous system is a privileged  site for antisense oligonucleotide action and not subject to the same  vagaries and pitfalls as non-neuronal systems. \u003cbr\u003e  \u003cem\u003eModulating Gene Expression by Antisense Oligonucleotides to  Understand\u003c\/em\u003e \u003cem\u003eNeural Functioning\u003c\/em\u003e contains chapters by experts in  the field that focus on the use of this technique in a variety of  behavioral systems, as well as rapid and nonspecific effects and the  uptake and metabolism of antisense oligonucleotides by the nervous  system. \u003cbr\u003e  \u003cem\u003eModulating Gene Expression by Antisense Oligonucleotides to  Understand\u003c\/em\u003e \u003cem\u003eNeural Functioning\u003c\/em\u003e features: \u003c\/p\u003e\u003cul\u003e  \u003cli\u003eexperts in the field reporting on the use of antisense  oligonucleotide technology in a variety of behavioral systems,  including pain control, circadian rhythms, ingestion and control of  water balance, and reproductive behaviors; \u003c\/li\u003e  \u003cli\u003ethe novel use of  plasmids to express antisense RNA in the nervous system; \u003c\/li\u003e  \u003cli\u003ethe  biodistribution and metabolism of antisense oligonucleotides in the  nervous system; \u003c\/li\u003e  \u003cli\u003erapid and unusual effects; and  \u003c\/li\u003e  \u003cli\u003enon-specific effects.\u003c\/li\u003e  \u003c\/ul\u003e \u003ch3\u003eDetails\u003c\/h3\u003e \u003cp\u003ePublished by: Springer\u003c\/p\u003e \u003cp\u003ePublication Date: 1998-10-31\u003c\/p\u003e \u003cp\u003eFormat: Hardcover\u003c\/p\u003e \u003cp\u003eISBN-13: 9780792382423\u003c\/p\u003e \u003cp\u003eDOI: 10.1007\/978-1-4615-4933-8\u003c\/p\u003e \u003cp\u003eDimensions: 235cm x155cm\u003c\/p\u003e \u003cp\u003ePages: 172\u003c\/p\u003e ","brand":"Springer US","offers":[{"title":"Default Title","offer_id":46312197259404,"sku":"9780792382423","price":152.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0710\/9545\/1788\/files\/9780792382423.jpg?v=1771521447","url":"https:\/\/lateknightbooks.com\/products\/9780792382423","provider":"Late Knight Books and Services, LLC","version":"1.0","type":"link"}