{"product_id":"9780792387084","title":"Glucocorticoid Therapy in Chronic Inflammatory Bowel Disease: From Basic Principles to Rational Therapy","description":"\u003ch1\u003eGlucocorticoid Therapy in Chronic Inflammatory Bowel Disease: From Basic Principles to Rational Therapy\u003c\/h1\u003e \u003ch2\u003eMollmann, H.W.; May, B.\u003c\/h2\u003e \u003cp\u003eThe clinical efficacy of glucocorticoids in the treatment of  inflammatory bowel disease has been confirmed in a multitude of  controlled monocentre and multicentre studies as well as from  observations of the clinical course of the disease. Although, in the  past, the treatment recommendations, dose regimen, substance selection  and mode of administration were deduced principally from clinical  trials, in recent years experimental research has yielded a mass of  therapeutically significant new results. This seeks to optimize the  clinical effects of the steroids and minimize their adverse events on  a rational basis by the application of the knowledge obtained in  pharmacokinetic and pharmacodynamic models, taking into account the  different types of protein binding and the intrinsic activity of the  various glucocorticoids. However, the transfer of this type of  `disease-adapted differential glucocorticoid treatment' into a  clinical context involves a critical examination of the `received'  notions that have characterized steroid treatment in the past, such as  strictly circadian administration or time-related dose reduction, as  well as proof of the clinical superiority of the new therapeutic  approaches. \u003cbr\u003e  This book, the proceedings of a workshop on Glucocorticoid Treatment  held in Strasbourg, France, identifies the current status of existing  therapeutic concepts in inflammatory bowel disease, presents the  pharmacokinetic and pharmacodynamic interactions in connection with  the specific pharmacological properties of steroids with reference to  substance differences and different modes of administration, and  demonstrates their therapeutic significance.\u003c\/p\u003e \u003ch3\u003eDetails\u003c\/h3\u003e \u003cp\u003ePublished by: Springer\u003c\/p\u003e \u003cp\u003ePublication Date: 1996-10-31\u003c\/p\u003e \u003cp\u003eFormat: Hardcover\u003c\/p\u003e \u003cp\u003eISBN-13: 9780792387084\u003c\/p\u003e \u003cp\u003eDOI: \u003c\/p\u003e \u003cp\u003eDimensions: 235.0cm x155.0cm\u003c\/p\u003e \u003cp\u003ePages: 128.0\u003c\/p\u003e ","brand":"Springer Netherlands","offers":[{"title":"Default Title","offer_id":44541625761932,"sku":"9780792387084","price":152.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/lateknightbooks.com\/products\/9780792387084","provider":"Late Knight Books and Services, LLC","version":"1.0","type":"link"}