{"product_id":"9780792387688","title":"Biology of Bile Acids in Health and Disease","description":"\u003ch1\u003eBiology of Bile Acids in Health and Disease\u003c\/h1\u003e \u003ch2\u003evan Berge Henegouwen, G.P.; Keppler, D.; Leuschner, U.; Paumgartner, G.; Stiehl, A.\u003c\/h2\u003e \u003cp\u003eBeginning in 1970, the International Bile Acid Meeting has  taken place every two years and each time new progress in our  understanding of the complex role of bile acids in many metabolic  processes of the liver and the intestine has been revealed by a  selected group of leading scientists from all over the world. \u003cbr\u003e  Although originally mainly physiological data on bile acid synthesis  and transport were emphasized, and later on also the therapeutic  benefit of bile acids in gallstone disease and cholestasis was  discovered, we have come now to the molecular biology and genetic era  with major discoveries in transport defects and related diseases. This  book is the proceedings of Falk Symposium No. 120, held in The Hague,  The Netherlands, on October 12-13, 2000 - the 16th  International Bile Acid Meeting. \u003cbr\u003e  One of the main discoveries recently has been the identification of  nuclear receptors for bile acids, which gives them a much broader  perspective than previously anticipated. It even suggests that bile  acids can regulate their biosynthesis and enterohepatic circulation  transcriptionally. It will therefore not be surprising that this  topic, together with the molecular regulation of cholesterol  7alpha-hydroxylase and cholesterol homeostasis, has a dominant place  in these proceedings. Another important topic is the progress in our  molecular understanding of hepatic (both at the basolateral and  canalicular sites), cholangiocytic and intestinal bile acid transport  processes. Further insights into genetic defects causing cholestasis  or intestinal malabsorption in animal models and in human diseases are  also discussed by a number of well-known authors. Finally the last  section deals with new findings on the role of bile acid therapy in  cholestatic syndromes or chemoprevention and with the potential  benefit of bile acid inhibitors. All contributors provide an update on  the most recent developments in their field.\u003c\/p\u003e \u003ch3\u003eDetails\u003c\/h3\u003e \u003cp\u003ePublished by: Springer\u003c\/p\u003e \u003cp\u003ePublication Date: 2001-05-31\u003c\/p\u003e \u003cp\u003eFormat: Hardcover\u003c\/p\u003e \u003cp\u003eISBN-13: 9780792387688\u003c\/p\u003e \u003cp\u003eDOI: \u003c\/p\u003e \u003cp\u003eDimensions: 233.0cm x155.0cm\u003c\/p\u003e \u003cp\u003ePages: 336.0\u003c\/p\u003e ","brand":"Springer Netherlands","offers":[{"title":"Default Title","offer_id":44541626450060,"sku":"9780792387688","price":152.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/lateknightbooks.com\/products\/9780792387688","provider":"Late Knight Books and Services, LLC","version":"1.0","type":"link"}