Infectious Disease

Hackett, Charles J.; Harn Jr, Donald A.

A cutting-edge review of the major research areas of adjuvant discovery, design, development, and use. The authors lay down a rational basis for vaccine adjuvant function and analyze a number of significantly distinct adjuvant-active molecules to illuminate the principles of their function and use. The focus is on specific receptor-ligand interactions, including the molecular features needed for a compound to possess adjuvant activity. The critical interface zone between the innate and adaptive immune systems is also analyzed to show how adjuvants exert their effects on T- and B-cell activation. Additional chapters address the possibility of tailoring adjuvants to yield optimally safe and effective responses.

Details

Published by: Humana

Publication Date: 2005-12-01

Format: Hardcover

ISBN-13: 9780896038929

DOI: 10.1007/978-1-59259-970-7

Dimensions: 235cm x155cm

Pages: 284