This book discusses US foreign and security policy in the contemporary Eastern Mediterranean against the backdrop of the war in Ukraine and renewed great power competition. It examines US relations with Turkey, Greece, and Cyprus and a balancing strategy in the region toward Russia. The author assesses the impact on Eastern Mediterranean politics and US interests, drawing on neorealist theories and the dynamics of an international system in transition, and explores the impact of the global redistribution of power in regions that do not traditionally constitute top strategic priorities. Contributing to discussions on great power balancing strategies and taking into consideration the transition to a post-unipolar international system, this book will appeal to scholars and students of international relations, security studies, US foreign and security policy, great power, and Mediterranean politics.