{"product_id":"9781071615447","title":"Methods in Pharmacology and Toxicology: In Vitro Methods and Protocols","description":"\u003ch1\u003eMethods in Pharmacology and Toxicology: In Vitro Methods and Protocols\u003c\/h1\u003e \u003ch2\u003eYan, Zhengyin; Caldwell, Gary W.\u003c\/h2\u003e \u003cp\u003eThis collection explores detailed experimental protocols necessary for setting up a variety of \u003ci\u003ein vitro\u003c\/i\u003e cytochrome P450 (CYP) assays that are vital in selecting drug candidates in a drug discovery pipeline. Major factors affecting drug metabolism include CYP expression levels, kinetic parameters for individual CYP enzymes, CYP inhibition and induction, time-dependent inhibition (TDI), CYP stability, non-CYP stability, UDP-glucuronosyltransferases (UGT) stability, excretion mechanisms, and drug-drug interactions (DDI), all addressed in this volume. Written for the \u003ci\u003eMethods in Pharmacology and Toxicology\u003c\/i\u003e series, chapters include helpful background information on the \u003ci\u003ein vitro\u003c\/i\u003e assay, a list of all the materials, reagents, and equipment necessary to carry out the assay, a step-by-step protocol, notes containing common and unexpected experimental problems in the assay, as well as references containing important supplementary reading. \u003c\/p\u003e\u003cdiv\u003e\u003cbr\u003e\u003c\/div\u003e\u003cdiv\u003eAuthoritativeand practical, \u003ci\u003eCytochrome P450: In Vitro Methods and Protocols\u003c\/i\u003e serves as a key guide for researchers in the area of discovery and development of new medicines. \u003c\/div\u003e \u003ch3\u003eDetails\u003c\/h3\u003e \u003cp\u003ePublished by: Humana\u003c\/p\u003e \u003cp\u003ePublication Date: 2022-07-10\u003c\/p\u003e \u003cp\u003eFormat: Paperback\u003c\/p\u003e \u003cp\u003eISBN-13: 9781071615447\u003c\/p\u003e \u003cp\u003eDOI: 10.1007\/978-1-0716-1542-3\u003c\/p\u003e \u003cp\u003eDimensions: 254cm x178cm\u003c\/p\u003e \u003cp\u003ePages: 379\u003c\/p\u003e ","brand":"Springer US","offers":[{"title":"Default Title","offer_id":47388019458188,"sku":"9781071615447","price":116.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0710\/9545\/1788\/files\/9781071615447.jpg?v=1775756678","url":"https:\/\/lateknightbooks.com\/products\/9781071615447","provider":"Late Knight Books and Services, LLC","version":"1.0","type":"link"}