This detailed new edition complements the previous edition with updates and new chemistry, concepts, and applications in the study of peptide nucleic acids (PNAs). The focus is on in vivo properties, behavior, and innovative applications of PNA, while maintaining contributions on both chemistry and nucleic acid recognition. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips for troubleshooting and avoiding known pitfalls.

Authoritative and up-to-date, Peptide Nucleic Acids: Methods and Protocols, Fourth Edition aims to inspire discovery and pursuit of new exciting avenues in the broad area of “artificial DNA.”