{"product_id":"9781118488133","title":"Evaluation of Enzyme Inhibitors in Drug Discovery A Guide for Medicinal Chemists and Pharmacologists","description":"\u003ch1\u003eEvaluation of Enzyme Inhibitors in Drug Discovery\u003c\/h1\u003e\u003ch2\u003eA Guide for Medicinal Chemists and Pharmacologists\u003c\/h2\u003e\u003ch3\u003eRobert A. Copeland\u003c\/h3\u003e\u003cdiv\u003e\u003cb\u003eScience \/ Life Sciences \/ Biochemistry\u003c\/b\u003e\u003c\/div\u003e\u003cbr\u003e\u003cdiv\u003e\n\u003cp\u003e\u003cb\u003eOffers essential guidance for discovering and optimizing novel drug therapies\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eUsing detailed examples, \u003ci\u003eEvaluation of Enzyme Inhibitors in Drug Discovery\u003c\/i\u003e equips researchers with the tools needed to apply the science of enzymology and biochemistry to the discovery, optimization, and preclinical development of drugs that work by inhibiting specific enzyme targets. Readers will applaud this book for its clear and practical presentations, including its expert advice on best practices to follow and pitfalls to avoid.\u003c\/p\u003e \u003cp\u003eThis \u003ci\u003eSecond Edition\u003c\/i\u003e brings the book thoroughly up to date with the latest research findings and practices. Updates explore additional forms of enzyme inhibition and special treatments for enzymes that act on macromolecular substrates. Readers will also find new discussions detailing the development and application of the concept of \u003ci\u003edrug-target residence time\u003c\/i\u003e.\u003c\/p\u003e \u003cp\u003e\u003ci\u003eEvaluation of Enzyme Inhibitors in Drug Discovery\u003c\/i\u003e begins by explaining why enzymes are such important drug targets and then examines enzyme reaction mechanisms. The book covers:\u003c\/p\u003e \u003cul\u003e \u003cli\u003eReversible modes of inhibitor interactions with enzymes\u003c\/li\u003e \u003cli\u003eAssay considerations for compound library screening\u003c\/li\u003e \u003cli\u003eLead optimization and structure-activity relationships for reversible inhibitors\u003c\/li\u003e \u003cli\u003eSlow binding and tight binding inhibitors\u003c\/li\u003e \u003cli\u003eDrug-target residence time\u003c\/li\u003e \u003cli\u003eIrreversible enzyme inactivators\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eThe book ends with a new chapter exploring the application of quantitative biochemical principles to the pharmacologic evaluation of drug candidates during lead optimization and preclinical development.\u003c\/p\u003e \u003cp\u003eThe \u003ci\u003eSecond Edition\u003c\/i\u003e of \u003ci\u003eEvaluation of Enzyme Inhibitors in Drug Discovery\u003c\/i\u003e continues to offer a treatment of enzymology applied to drug discovery that is quantitative and mathematically rigorous. At the same time, the clear and simple presentations demystify the complex science of enzymology, making the book accessible to many fields— from pharmacology to medicinal chemistry to biophysics to clinical medicine.\u003c\/p\u003e\n\u003c\/div\u003e\u003cdiv\u003e  \u003cp\u003e\u003cb\u003eROBERT A. COPELAND, PhD,\u003c\/b\u003e is Executive Vice President and Chief Scientific Officer at Epizyme, Inc., a biopharmaceutical company in Cambridge, Massachusetts. He is on the Editorial Board of \u003ci\u003eThe\u003c\/i\u003e \u003ci\u003eJournal of Biological Chemistry\u003c\/i\u003e and a member of the Faculty of 1000. Dr. Copeland has contributed more than 175 publications to the scientific literature and holds eight U.S.-issued patents. He has authored several books in protein science and enzymology, including \u003ci\u003eEnzymes: A Practical Introduction to Structure, Mechanism, and Data Analysis, Second Edition\u003c\/i\u003e (Wiley).\u003c\/p\u003e\n\u003c\/div\u003e\u003cbr\u003e\u003ctable\u003e\n\u003ctr\u003e\n\u003ctd\u003ePublication Date: \u003c\/td\u003e\n\u003ctd\u003e18 March 2013\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePublisher: \u003c\/td\u003e\n\u003ctd\u003eWiley\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eImprint: \u003c\/td\u003e\n\u003ctd\u003eWiley-Interscience\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eISBN-13: \u003c\/td\u003e\n\u003ctd\u003e9781118488133\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eFormat: \u003c\/td\u003e\n\u003ctd\u003eHardback\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePage Count: \u003c\/td\u003e\n\u003ctd\u003e576\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eWeight (oz): \u003c\/td\u003e\n\u003ctd\u003e32.32\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/table\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":44383905153164,"sku":"9781118488133","price":149.35,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0710\/9545\/1788\/files\/9781118488133.jpg?v=1780201731","url":"https:\/\/lateknightbooks.com\/products\/9781118488133","provider":"Late Knight Books and Services, LLC","version":"1.0","type":"link"}