Details methods for computing valid limits of detection.

• Clearly explains analytical detection limit theory, thereby mitigating incorrect detection limit concepts, methodologies and results
• Extensive use of computer simulations that are freely available to readers
• Curated short-list of important references for limits of detection
• Videos, screencasts, and animations are provided at an associated website, to enhance understanding
• Illustrated, with many detailed examples and cogent explanations

Edward Voigtman is emeritus professor of chemistry at the University of Massachusetts – Amherst, having retired after 29 years as a faculty member. His interests include ultrasensitive detection techniques, applications of signal/noise theory, optical calculus-based computer simulation of spectrometric systems and analytical detection limit theory and practice.