{"product_id":"9781119535287","title":"Animal Models for the Development of Cancer Immunotherapy","description":"\u003ch1\u003eAnimal Models for the Development of Cancer Immunotherapy\u003c\/h1\u003e\u003ch3\u003eSeng-Lai Tan\u003c\/h3\u003e\u003cdiv\u003e\u003cb\u003eMedical \/ Pharmacology\u003c\/b\u003e\u003c\/div\u003e\u003cbr\u003e\u003cdiv\u003eAnimal Models for the \u003cb\u003eDevelopment of Cancer Immunotherapy\u003c\/b\u003e \u003cp\u003e\u003cb\u003eProvides readers with a clear understanding of the value and challenges of using common and emerging preclinical models in cancer immunotherapy research and development.\u003c\/b\u003e \u003c\/p\u003e\n\u003cp\u003eAnimal models are essential tools for studying a range of issues in preclinical and clinical research on therapies targeting cancerous tumors. As clinical trials of advances in cancer immunotherapy are predicted to outpace preclinical research in the near future, there remains an urgent need to develop better animal models for preclinical evaluation of novel modulators. \u003ci\u003eAnimal Models for the Development of Cancer Immunotherapy\u003c\/i\u003e provides a detailed overview of different preclinical model systems for development of novel cancer immunotherapies while highlighting how key aspects of individual models translate into clinical findings. \u003c\/p\u003e\n\u003cp\u003eCovering the introduction, development, and therapeutic applications of animal models for cancer immunotherapy, this comprehensive volume helps pharmacologists identify suitable animal models, design pharmacological or translational studies, and advance their mechanistic understanding of therapeutic agents, and increase the possibility of success for novel immunotherapies in clinical settings. Chapters written by prominent leaders in the field address specific models that evaluate immuno-oncology drugs are supported by in-depth case studies and extensive references throughout. \u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eEmphasizes the importance of modeling tumor metastasis in preclinical models for efficient translation of findings into the clinic\u003c\/li\u003e \u003cli\u003eExplores recently discovered mechanisms of resistance and their preclinical modeling\u003c\/li\u003e \u003cli\u003eHighlights the unique characteristics and features of autologous and allogeneic approaches for humanization of mouse models\u003c\/li\u003e \u003cli\u003eReviews development of bone marrow-liver-thymus (BLT) immune humanized mice and emerging alternative models such as genetically engineered mouse models (GEMM)\u003c\/li\u003e \u003cli\u003eDiscusses alternative animal models for cancer research such as severe combined immunodeficiency (SCID) pigs\u003c\/li\u003e\n\u003c\/ul\u003e \u003cp\u003e\u003ci\u003eAnimal Models for the Development of Cancer Immunotherapy\u003c\/i\u003e is an essential resource for scientists and researchers in the pharmaceutical and biotechnology industries, medicinal chemists and biochemists, cell and molecular biologists, pharmacologists, immunologists, and clinicians.\u003c\/p\u003e\n\u003c\/div\u003e\u003cdiv\u003e \u003cp\u003e\u003cb\u003eSeng-Lai Tan, PhD,\u003c\/b\u003e is Chief Scientific Officer at Immunitas Therapeutics. He has more than 20 years of drug discovery and development experience in both small and large molecule therapeutic modalities, including multi-specific antibodies and stapled peptides. He is former Head of Immunology at Marengo (Elstar) Therapeutics and Forma Therapeutics, and has held leadership positions at EMD Serono Research \u0026amp; Development Institute and Roche.\u003c\/p\u003e \u003c\/div\u003e\u003cbr\u003e\u003ctable\u003e\n\u003ctr\u003e\n\u003ctd\u003ePublication Date: \u003c\/td\u003e\n\u003ctd\u003e23 August 2022\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePublisher: \u003c\/td\u003e\n\u003ctd\u003eWiley\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eImprint: \u003c\/td\u003e\n\u003ctd\u003eWiley\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eISBN-13: \u003c\/td\u003e\n\u003ctd\u003e9781119535287\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eFormat: \u003c\/td\u003e\n\u003ctd\u003eHardback\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePage Count: \u003c\/td\u003e\n\u003ctd\u003e320\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eWeight (oz): \u003c\/td\u003e\n\u003ctd\u003e16.0\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/table\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":44383969902732,"sku":"9781119535287","price":161.95,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0710\/9545\/1788\/files\/9781119535287_7b8cf684-fe4c-4a7a-850a-29bdf31b8db2.jpg?v=1780169521","url":"https:\/\/lateknightbooks.com\/products\/9781119535287","provider":"Late Knight Books and Services, LLC","version":"1.0","type":"link"}