{"product_id":"9781405176293","title":"Metal Complex - DNA Interactions","description":"\u003ch1\u003eMetal Complex - DNA Interactions\u003c\/h1\u003e\u003ch3\u003eNick Hadjiliadis | Einar Sletten\u003c\/h3\u003e\u003cdiv\u003e\u003cb\u003eScience \/ Chemistry \/ Inorganic\u003c\/b\u003e\u003c\/div\u003e\u003cbr\u003e\u003cdiv\u003e\n\u003cp\u003eMetal ions and metal complexes have long been recognized as critically important components of nucleic acid chemistry, both in regulation of gene expression and as promising therapeutic agents. Understanding how metal complexes interact with DNA has become an active research area at the interface between chemistry, molecular biology and medicine.\u003c\/p\u003e \u003cp\u003e\u003ci\u003eMetal Complex - DNA Interactions\u003c\/i\u003e provides a comprehensive overview of this increasingly diverse field, presenting recent developments and the latest research with particular emphasis on metal-based drugs and metal ion toxicity. The text is divided into four parts:\u003c\/p\u003e \u003cul\u003e \u003cli\u003e\n\u003ci\u003eBasic Structural and Kinetic Aspects:\u003c\/i\u003e includes chapters on sequence-selective metal binding to DNA and thermodynamic models.\u003c\/li\u003e \u003cli\u003e\n\u003ci\u003eMedical Applications:\u003c\/i\u003e focuses on anticancer platinum drugs, including discussions on DNA repair in antitumor effects of platinum drugs and photo-dynamic therapy.\u003c\/li\u003e \u003cli\u003e\n\u003ci\u003eDNA-Recognition - Nucleases and Sensor\u003c\/i\u003e: describes probes for DNA recognition, artificial restriction agents, metallo-DNAzymes for metal sensing applications and metal ion dependent catalysis in nucleic acid enzymes.\u003c\/li\u003e \u003cli\u003e\n\u003ci\u003eToxicological Aspects:\u003c\/i\u003e deals with structural studies of mercury–DNA interactions, chromium-induced DNA damage and repair, and the effect of arsenic and nickel on DNA integrity.\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eThis book will be a valuable resource for academic researchers and professionals from a range of pharmaceutical and chemical industries, particularly those involved in the development of new and less toxic anticancer metallo-drugs, and in the field of environmental and toxicological chemistry.\u003c\/p\u003e\n\u003c\/div\u003e\u003cdiv\u003e Nikolaos Hadjiliadis is Professor in the Dept of Chemistry at the University of Ioannina, Greece. Einar Sletten is Professor in the Dept of Chemistry at the University of Bergen, Norway.\u003c\/div\u003e\u003cbr\u003e\u003ctable\u003e\n\u003ctr\u003e\n\u003ctd\u003ePublication Date: \u003c\/td\u003e\n\u003ctd\u003e18 May 2009\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePublisher: \u003c\/td\u003e\n\u003ctd\u003eWiley\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eImprint: \u003c\/td\u003e\n\u003ctd\u003eWiley-Blackwell\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eISBN-13: \u003c\/td\u003e\n\u003ctd\u003e9781405176293\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eFormat: \u003c\/td\u003e\n\u003ctd\u003eHardback\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePage Count: \u003c\/td\u003e\n\u003ctd\u003e544\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eWeight (oz): \u003c\/td\u003e\n\u003ctd\u003e37.76\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/table\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":44384771637388,"sku":"9781405176293","price":192.56,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0710\/9545\/1788\/files\/9781405176293.jpg?v=1780192491","url":"https:\/\/lateknightbooks.com\/products\/9781405176293","provider":"Late Knight Books and Services, LLC","version":"1.0","type":"link"}