{"product_id":"9781441902252","title":"Synaptic Plasticity in Pain","description":"\u003ch1\u003eSynaptic Plasticity in Pain\u003c\/h1\u003e\u003ch3\u003eMarzia Malcangio\u003c\/h3\u003e\u003cdiv\u003e\u003cb\u003eScience \/ Life Sciences \/ Neuroscience\u003c\/b\u003e\u003c\/div\u003e\u003cbr\u003e\u003cdiv\u003e\u003cp\u003ePrimary sensory neurons respond to peripheral stimulation and project to the spinal cord. Specifically, the population of neurons which respond to damaging stimuli terminate in the superficial layers of the dorsal horn. Therefore, the dorsal horns constitute the first relay site for nociceptive fibre terminals which make synaptic contacts with second order neurons. It has recently become clear that the strength of this first pain synapse is plastic and modifiable by several modulators, including neuronal and non-neuronal regulators, and studies on the fundamental processes regulating the plasticity of the first pain synapse have resulted in the identification of new targets for the treatment of chronic pain. This book will be of interest to a wide readership in the pain field.\u003c\/p\u003e\u003c\/div\u003e\u003cdiv\u003e\n\u003cp\u003eAbout the Author:\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003eDr. Marzia Malcangio holds a bachelors' degree in pharmaceutical chemistry and a PhD in Pharmacology from the University of Florence, Italy. She spent most of her active scientific life in London UK, establishing an internationally renowned laboratory devoted to the biology of spinal cord mechanisms underlying chronic pain. Her current work explores novel approaches for targeting neuropathic and arthritic pain unveiling, and the involvement of microglia and the mechanisms governing microglial-neuronal communication. Dr Malcangio lives in London with her husband and two sons.\u003c\/p\u003e\n\u003c\/div\u003e\u003cbr\u003e\u003ctable\u003e\n\u003ctr\u003e\n\u003ctd\u003ePublication Date: \u003c\/td\u003e\n\u003ctd\u003e10 July 2009\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePublisher: \u003c\/td\u003e\n\u003ctd\u003eSpringer New York\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eImprint: \u003c\/td\u003e\n\u003ctd\u003eSpringer\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eISBN-13: \u003c\/td\u003e\n\u003ctd\u003e9781441902252\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eFormat: \u003c\/td\u003e\n\u003ctd\u003eHardback\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePage Count: \u003c\/td\u003e\n\u003ctd\u003e504\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/table\u003e","brand":"Springer New York","offers":[{"title":"Default Title","offer_id":51557219926156,"sku":"9781441902252","price":197.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0710\/9545\/1788\/files\/9781441902252.jpg?v=1784777026","url":"https:\/\/lateknightbooks.com\/products\/9781441902252","provider":"Late Knight Books and Services, LLC","version":"1.0","type":"link"}