{"product_id":"9781461482284","title":"Transporters in Drug Development: Discovery, Optimization, Clinical Study and Regulation","description":"\u003ch1\u003eTransporters in Drug Development: Discovery, Optimization, Clinical Study and Regulation\u003c\/h1\u003e \u003ch2\u003eSugiyama, Yuichi; Steffansen, Bente\u003c\/h2\u003e \u003cp\u003e\u003c\/p\u003e\u003cp\u003e\u003ci\u003eTransporters in Drug Development\u003c\/i\u003e examines how membrane transporters can be dealt with in academic–industrial drug discovery and pharmaceutical development as well as from a regulatory perspective. The book describes methods and examples of \u003ci\u003ein vitro\u003c\/i\u003e characterization of single transporters in the intestines, liver and kidneys as well as characterization of substrate overlap between various transporters. Furthermore, probes and biomarkers are suggested for studies of the transporters’ impact on the pharmacokinetics of drug substrates\/candidates interacting on transporters. The challenges of translating \u003ci\u003ein vitro\u003c\/i\u003e observed interaction of transporters into \u003ci\u003ein vivo\u003c\/i\u003e relevance are explored, and the book highlights perspectives of applying targeted proteomics and mechanistic modeling in this process. \u003c\/p\u003e \u003ch3\u003eDetails\u003c\/h3\u003e \u003cp\u003ePublished by: Springer\u003c\/p\u003e \u003cp\u003ePublication Date: 2013-09-17\u003c\/p\u003e \u003cp\u003eFormat: Hardcover\u003c\/p\u003e \u003cp\u003eISBN-13: 9781461482284\u003c\/p\u003e \u003cp\u003eDOI: 10.1007\/978-1-4614-8229-1\u003c\/p\u003e \u003cp\u003eDimensions: 235cm x155cm\u003c\/p\u003e \u003cp\u003ePages: 317\u003c\/p\u003e ","brand":"Springer","offers":[{"title":"Default Title","offer_id":44398732738700,"sku":"9781461482284","price":153.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0710\/9545\/1788\/files\/9781461482284.jpg?v=1755442655","url":"https:\/\/lateknightbooks.com\/products\/9781461482284","provider":"Late Knight Books and Services, LLC","version":"1.0","type":"link"}