{"product_id":"9781493953905","title":"Advances in Experimental Medicine and Biology","description":"\u003ch1\u003eAdvances in Experimental Medicine and Biology\u003c\/h1\u003e \u003ch2\u003eLiebermann, Dan A.; Hoffman, Barbara\u003c\/h2\u003e \u003cp\u003eEmerging evidence indicates that the Gadd45 family of genes play a unique and critical role as sensors of stress, including genotoxic, physiological and oncogenic stress.   The stress response Gadd45 family of genes (Gadd45a, Gadd45b \u0026amp; Gadd45g), discovered by Dr. Liebermann and other researchers, encode for small (18 kd) nuclear\/cytoplasmic proteins).  These genes are rapidly induced by a wide variety of endogenous and exogenous stress stimuli. In spite of marked similarities, Gadd45 genes are regulated differently \u0026amp; exhibit functional diversity.  Gadd45 are implicated in cell cycle arrest, DNA demethylation \u0026amp; repair, apoptosis, cell survival, genomic stability, inflammation, \u0026amp; in response to physiological and oncogenic stress.   Functions of Gadd45 genes are mediated by protein-protein interactions that modulate structure\/function of other cellular proteins implicated in cell cycle regulation and the response of cells to stress; these interactions vary depending upon the biological setting including cell type, developmental stage and stress\/stimulus.  Protein partners include cdc2\/cyclinB1, p21, the p38\/JNK stress induced kinase pathways, and PCNA\/histones. The purpose of this book is to provide a comprehensive picture of the unique global role Gadd45 genes play as stress sensors \u0026amp; the molecular pathways involved.\u003c\/p\u003e \u003ch3\u003eDetails\u003c\/h3\u003e \u003cp\u003ePublished by: Springer\u003c\/p\u003e \u003cp\u003ePublication Date: 2016-08-23\u003c\/p\u003e \u003cp\u003eFormat: Paperback\u003c\/p\u003e \u003cp\u003eISBN-13: 9781493953905\u003c\/p\u003e \u003cp\u003eDOI: 10.1007\/978-1-4614-8289-5\u003c\/p\u003e \u003cp\u003eDimensions: 235cm x155cm\u003c\/p\u003e \u003cp\u003ePages: 134\u003c\/p\u003e ","brand":"Springer New York","offers":[{"title":"Default Title","offer_id":47378607669388,"sku":"9781493953905","price":125.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0710\/9545\/1788\/files\/9781493953905.jpg?v=1775708517","url":"https:\/\/lateknightbooks.com\/products\/9781493953905","provider":"Late Knight Books and Services, LLC","version":"1.0","type":"link"}