{"product_id":"9781555819309","title":"Antibiotics Challenges, Mechanisms, Opportunities","description":"\u003ch3\u003eASM Books\u003c\/h3\u003e\u003ch1\u003eAntibiotics\u003c\/h1\u003e\u003ch2\u003eChallenges, Mechanisms, Opportunities\u003c\/h2\u003e\u003ch3\u003eChristopher Walsh | Timothy Wencewicz\u003c\/h3\u003e\u003cdiv\u003e\u003cb\u003eMedical \/ Microbiology\u003c\/b\u003e\u003c\/div\u003e\u003cbr\u003e\u003cdiv\u003e\n\u003cp\u003e\u003cb\u003eA chemocentric view of the molecular structures of antibiotics, their origins, actions, and major categories of resistance\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003ci\u003eAntibiotics: Challenges, Mechanisms, Opportunities\u003c\/i\u003e focuses on antibiotics as small organic molecules, from both natural and synthetic sources. Understanding the chemical scaffold and functional group structures of the major classes of clinically useful antibiotics is critical to understanding how antibiotics interact selectively with bacterial targets.\u003c\/p\u003e \u003cp\u003eThis textbook details how classes of antibiotics interact with five known robust bacterial targets: cell wall assembly and maintenance, membrane integrity, protein synthesis, DNA and RNA information transfer, and the folate pathway to deoxythymidylate. It also addresses the universe of bacterial resistance, from the concept of the resistome to the three major mechanisms of resistance: antibiotic destruction, antibiotic active efflux, and alteration of antibiotic targets. \u003ci\u003eAntibiotics\u003c\/i\u003e also covers the biosynthetic machinery for the major classes of natural product antibiotics.\u003c\/p\u003e \u003cp\u003eAuthors Christopher Walsh and Timothy Wencewicz provide compelling answers to these questions:\u003c\/p\u003e \u003cul\u003e \u003cli\u003eWhat are antibiotics?\u003c\/li\u003e \u003cli\u003eWhere do antibiotics come from?\u003c\/li\u003e \u003cli\u003eHow do antibiotics work?\u003c\/li\u003e \u003cli\u003eWhy do antibiotics stop working?\u003c\/li\u003e \u003cli\u003eHow should our limited inventory of effective antibiotics be addressed?\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003e\u003ci\u003eAntibiotics\u003c\/i\u003e is a textbook for graduate courses in chemical biology, pharmacology, medicinal chemistry, and microbiology and biochemistry courses. It is also a valuable reference for microbiologists, biological and natural product chemists, pharmacologists, and research and development scientists.\u003c\/p\u003e\n\u003c\/div\u003e\u003cbr\u003e\u003ctable\u003e\n\u003ctr\u003e\n\u003ctd\u003ePublication Date: \u003c\/td\u003e\n\u003ctd\u003e17 February 2016\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePublisher: \u003c\/td\u003e\n\u003ctd\u003eWiley\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eImprint: \u003c\/td\u003e\n\u003ctd\u003eASM Press\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eISBN-13: \u003c\/td\u003e\n\u003ctd\u003e9781555819309\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eFormat: \u003c\/td\u003e\n\u003ctd\u003eHardback\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePage Count: \u003c\/td\u003e\n\u003ctd\u003e477\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eWeight (oz): \u003c\/td\u003e\n\u003ctd\u003e36.0\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/table\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":44310456238220,"sku":"9781555819309","price":120.56,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0710\/9545\/1788\/files\/9781555819309_de51d3d0-2c4d-41f2-bcf1-3c894a1ea78f.jpg?v=1780194767","url":"https:\/\/lateknightbooks.com\/products\/9781555819309","provider":"Late Knight Books and Services, LLC","version":"1.0","type":"link"}