{"product_id":"9781555819552","title":"Tuberculosis and the Tubercle Bacillus","description":"\u003ch3\u003eASM Books\u003c\/h3\u003e\u003ch1\u003eTuberculosis and the Tubercle Bacillus\u003c\/h1\u003e\u003ch3\u003eWilliam R. Jacobs | Helen McShane | Valerie Mizrahi | Ian M. Orme\u003c\/h3\u003e\u003cdiv\u003e\u003cb\u003eMedical \/ Infectious Diseases\u003c\/b\u003e\u003c\/div\u003e\u003cbr\u003e\u003cdiv\u003e\n\u003cp\u003e\u003cb\u003eCan today's innovative practices and molecular tools tame this ancient disease?\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eOne third of the world's population is infected with tuberculosis (TB), with about 10 million new cases annually. To combat TB and its agent, Mycobacterium tuberculosis, the World Health Organization launched The End TB Strategy, which aims to slash the suffering and cost of TB by 2035.\u003c\/p\u003e \u003cp\u003eThis makes the second edition of \u003ci\u003eTuberculosis and the Tubercle Bacillus\u003c\/i\u003e, edited by Jacobs, McShane, Mizrahi, and Orme, an extremely valuable resource for scientists and clinicians. The editors have gathered their colleagues from around the world to present the latest on the molecular biology of \u003ci\u003eM. tuberculosis\u003c\/i\u003e and related species, the host-pathogen interactions that enable invasion, and the host's immune response to \u003ci\u003eM. tuberculosis\u003c\/i\u003e infection. The basic, clinical, and translational research presented in this book supports the goals of WHO's End TB Strategy by driving toward the development of effective vaccines, rapid molecular diagnostics, and anti-TB drugs.\u003c\/p\u003e \u003cul\u003e \u003cli\u003eCreating an effective tuberculosis vaccine. Understand the innate and adaptive immune response to \u003ci\u003eM. tuberculosis\u003c\/i\u003e infection, its study in established animal models, and how this information is being used to develop new vaccines against TB.\u003c\/li\u003e \u003cli\u003eFormulating new antituberculosis drugs. Learn the challenges and methods for evaluating new drugs in preclinical trials with a focus on drugs that work against \"persisters\" and those that act on the electron transport complex and ATP synthase of \u003ci\u003eM. tuberculosis\u003c\/i\u003e.\u003c\/li\u003e \u003cli\u003eOvercoming the challenges of diagnosing tuberculosis. Review new diagnostic tools that are simple, rapid, affordable, specific, sensitive, and safe, including molecular-based diagnostic methods such as GeneXpert MTB\/RIF.\u003c\/li\u003e \u003cli\u003eUsing molecular, genomic, and bioinformatics tools to understand the biology and evolution of \u003ci\u003eMycobacterium\u003c\/i\u003e. Explore current research on the molecular mechanisms that \u003ci\u003eM. tuberculosis\u003c\/i\u003e uses to evade the immune system, enter a state of nonreplicating persistence, and become reactivated.\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eThe second edition of \u003ci\u003eTuberculosis and the Tubercle Bacillus\u003c\/i\u003e presents the latest research on a microorganism that is exquisitely well adapted to its human host. This pathogen continues to confound scientists, clinicians, and public health specialists, who will all find much valuable information in this comprehensive set of reviews.\u003c\/p\u003e\n\u003c\/div\u003e\u003cbr\u003e\u003ctable\u003e\n\u003ctr\u003e\n\u003ctd\u003ePublication Date: \u003c\/td\u003e\n\u003ctd\u003e20 September 2017\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePublisher: \u003c\/td\u003e\n\u003ctd\u003eWiley\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eImprint: \u003c\/td\u003e\n\u003ctd\u003eASM Press\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eISBN-13: \u003c\/td\u003e\n\u003ctd\u003e9781555819552\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eFormat: \u003c\/td\u003e\n\u003ctd\u003eHardback\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePage Count: \u003c\/td\u003e\n\u003ctd\u003e730\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eWeight (oz): \u003c\/td\u003e\n\u003ctd\u003e82.4\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/table\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":44315875213452,"sku":"9781555819552","price":117.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0710\/9545\/1788\/files\/9781555819552_8d679de5-cf4e-4df4-85c9-22ae7b708053.jpg?v=1780156263","url":"https:\/\/lateknightbooks.com\/products\/9781555819552","provider":"Late Knight Books and Services, LLC","version":"1.0","type":"link"}