This volume explores the effects of glucocorticoids on mood and the mechanisms mediating these effects, including aspects of the clinical effects of glucocorticoids in a variety of illnesses and in health, including molecular mechanisms, glucocorticoid resistance and sensitivity, glucocorticoid receptor polymorphisms, and implications for therapy. In light of the important clinical implications for treatment of a wide range of diseases with glucocorticoids and the potential serious side effects of depression and suicidality, it is timely that this subject be re-visited due to new research. The topics addressed include a survey of clinical features of glucocorticoid treatment and molecular and genetic factors in glucocorticoid resistance and sensitivity and are of relevance to many medical specialties in which glucocorticoid therapy is widely used, including  rheumatology, orthopedics, pain management, allergy/immunology and asthma.

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At UCSD, where he has taught for over 35 years, Dr. Judd directs basic and clinical research focused on severe brain and behavior disorders throughout the life cycle. His department centers on mood disorders, late-onset psychoses, neurobehavioral aspects of HIV infection, child and adolescent services research and many other clinical and basic research programs.