Methods in Molecular Medicine: Methods and Protocols

Ludewig, Burkhard; Hoffmann, Matthias W.

An authoritative collection of optimal techniques for producing and characterizing the immunologically active cells and effector molecules now gaining wide use in the clinical treatment of patients. Taking advantage of the latest technologies, the authors present readily reproducible experimental protocols for the study of dendritic cells, T cells, monoclonal antibodies, and bone marrow transplantation. The emphasis is on preclinicical and clinical applications and on the progress of selected approaches in clinical trials. Additional chapters cover the molecular definition of target antigens, mathematical modeling approaches to immunotherapy, and the utilization of regulatory T cells. The protocols make it possible to study the adoptive transfer of tailored antigen-specific immune cells and to improve the clinical application of adoptive immunotherapy.

Details

Published by: Humana

Publication Date: 2010-11-09

Format: Paperback

ISBN-13: 9781617375460

DOI: 10.1385/1592598625

Dimensions: 229cm x152cm

Pages: 500