The Serotonin Receptors: From Molecular Pharmacology to Human Therapeutics

Roth, Bryan L.

A comprehensive, state-of-the-art review of our current understanding of the molecular and structural biology of 5-HT receptors and their potential use for drug discovery. The authors describe the anatomical, cellular, and subcellular distribution of 5-HT receptors and demonstrate a powerful approach to elucidating their physiological role using knockout mice in which the 5-HT receptors were deleted. They also review our understanding of the physiological role(s) of 5-HT receptors based mainly on studies performed in genetically engineered mice. Highlights include discussions of the behavioral phenotypes of 5-HT receptor knockout animals, the molecular biology and pharmacology of 5-HT receptors, and insights into the complexity of 5-HT receptor signal transduction.

Details

Published by: Humana

Publication Date: 2010-11-09

Format: Paperback

ISBN-13: 9781617376474

DOI: 10.1007/978-1-59745-080-5

Dimensions: 229.0cm x152.0cm

Pages: 618.0