{"product_id":"9781617797583","title":"Stem Cell Biology and Regenerative Medicine","description":"\u003ch1\u003eStem Cell Biology and Regenerative Medicine\u003c\/h1\u003e \u003ch2\u003eAllan, Alison L.\u003c\/h2\u003e \u003cp\u003e\u003c\/p\u003e\u003cp\u003eThe “cancer stem cell” hypothesis postulates that cancer arises from a subpopulation of tumor-initiating cells or cancer stem cells (CSCs). While the idea of cancer stem cells has been around for more than a hundred years, evidence from the fields of hematology and cancer biology has now demonstrated the critical role of stem cells in hematological malignancies and suggested that these same mechanisms are also central to the initiation, progression, and treatment of solid cancers. Clinical and experimental studies have shown that CSCs exhibit many classical properties of normal stem cells, including a high self-renewal capacity and the ability to generate heterogeneous lineages; the requirement for a specific “niche”\/microenvironment to grow; and an increased capacity for self-protection against harsh environments, toxins, and drugs. \u003c\/p\u003e\u003cp\u003e\u003ci\u003e \u003c\/i\u003e\u003c\/p\u003e\u003cp\u003e\u003ci\u003eCancer Stem Cells in Solid Tumors\u003c\/i\u003e represents a detailed overview of cancer stem cells and their role in solid cancers. Comprised of 24 chapters, this volume will provide readers with a comprehensive understanding of this important and evolving field.\u003c\/p\u003e\u003cp\u003e \u003c\/p\u003e\u003cp\u003eTopics covered include:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eIntroduction of the CSC hypothesis\u003c\/li\u003e\n\u003cli\u003eHistorical perspectives and the contributing lessons from leukemia\u003c\/li\u003e\n\u003cli\u003eCurrent knowledge regarding the identification and role of CSCs in various forms of solid cancer including breast, brain, colorectal, pancreatic, prostate, melanoma, lung, ovarian, hepatocellular, and head and neck cancer \u003c\/li\u003e\n\u003cli\u003eMolecular pathways involved in driving CSC function, with a particular focus on the novel convergence of embryonic and tumorigenic signaling pathways\u003c\/li\u003e\n\u003cli\u003e\n\u003ci\u003eIn vitro\u003c\/i\u003e and \u003ci\u003ein vivo\u003c\/i\u003e assays, model systems, and imaging modalities for studying CSCs\u003c\/li\u003e\n\u003cli\u003eThe clinical importance of CSCs for cancer management and treatment, including important implications for prognosis, prediction, and treatment resistance\u003c\/li\u003e\n\u003cli\u003eConsideration of the controversy surrounding the CSC hypothesis and important unanswered questions in this field\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e \u003c\/p\u003e\u003cp\u003eThis collective work was written by a group of prominent international experts in cancer biology, oncology, and\/or stem cell biology. It will serve as a valuable resource for established researchers, professors, health care professionals, and students in the medical and scientific community who are investigating stem cells and\/or oncology.\u003c\/p\u003e \u003ch3\u003eDetails\u003c\/h3\u003e \u003cp\u003ePublished by: Humana\u003c\/p\u003e \u003cp\u003ePublication Date: 2013-10-24\u003c\/p\u003e \u003cp\u003eFormat: Paperback\u003c\/p\u003e \u003cp\u003eISBN-13: 9781617797583\u003c\/p\u003e \u003cp\u003eDOI: 10.1007\/978-1-61779-246-5\u003c\/p\u003e \u003cp\u003eDimensions: 235cm x155cm\u003c\/p\u003e \u003cp\u003ePages: 478\u003c\/p\u003e ","brand":"Humana Press","offers":[{"title":"Default Title","offer_id":50148630855820,"sku":"9781617797583","price":206.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0710\/9545\/1788\/files\/9781617797583.jpg?v=1779566561","url":"https:\/\/lateknightbooks.com\/products\/9781617797583","provider":"Late Knight Books and Services, LLC","version":"1.0","type":"link"}