{"product_id":"9783030117474","title":"Translational Research Methods in Diabetes, Obesity, and Nonalcoholic Fatty Liver Disease: A Focus on Early Phase Clinical Drug Development","description":"\u003ch1\u003eTranslational Research Methods in Diabetes, Obesity, and Nonalcoholic Fatty Liver Disease: A Focus on Early Phase Clinical Drug Development\u003c\/h1\u003e \u003ch2\u003eKrentz, Andrew J.; Weyer, Christian; Hompesch, Marcus\u003c\/h2\u003e \u003cp\u003e\u003c\/p\u003e\u003cp\u003eThis book aims to aid the selection of the most appropriate methods for use in early phase (1 and 2) clinical studies of new drugs for diabetes, obesity, non-alcoholic fatty liver disease (NAFLD) and related cardiometabolic disorders.\u003c\/p\u003e\u003cp\u003eClinical research methods to assess the pharmacokinetics and pharmacodynamics of new diabetes drugs, e.g. the euglycemic clamp technique, have become well-established in proof-of-mechanism studies.  However, selection of the most appropriate techniques is by no means straightforward. Moreover, the application of such methods must conform to the regulatory requirements for new drugs.\u003c\/p\u003e\u003cp\u003eThis book discusses the need for new pharmacotherapies for diabetes, obesity and NAFLD and the molecular targets of drugs currently in development.  Emerging technologies including functional imaging, circulating biomarkers and omics are considered together with practical and ethical issues pertaining to early phase clinical trials in subjects with cardiometabolic disorders.\u003c\/p\u003e\u003cp\u003e\u003ci\u003eTranslational Research Methods in Diabetes, Obesity, and Non-Alcoholic Fatty Liver Disease\u003c\/i\u003e is of interest to biomedical scientists, pharmacologists, academics involved in metabolic research and clinicians practicing in these specialties.\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e \u003ch3\u003eDetails\u003c\/h3\u003e \u003cp\u003ePublished by: Springer\u003c\/p\u003e \u003cp\u003ePublication Date: 2019-04-12\u003c\/p\u003e \u003cp\u003eFormat: Hardcover\u003c\/p\u003e \u003cp\u003eISBN-13: 9783030117474\u003c\/p\u003e \u003cp\u003eDOI: 10.1007\/978-3-030-11748-1\u003c\/p\u003e \u003cp\u003eDimensions: 254cm x178cm\u003c\/p\u003e \u003cp\u003ePages: 556\u003c\/p\u003e ","brand":"Springer International Publishing","offers":[{"title":"Default Title","offer_id":46413335363724,"sku":"9783030117474","price":161.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0710\/9545\/1788\/files\/9783030117474.jpg?v=1772032961","url":"https:\/\/lateknightbooks.com\/products\/9783030117474","provider":"Late Knight Books and Services, LLC","version":"1.0","type":"link"}