This book introduces a series of problems and methods insufficiently discussed in the field of Fractional Calculus – a major, emerging tool relevant to all areas of scientific inquiry. The authors present examples based on symbolic computation, written in Maple and Mathematica, and address both mathematical and computational areas in the context of mathematical modeling and the generalization of classical integer-order methods. Distinct from most books, the present volume fills the gap between mathematics and computer fields, and the transition from integer- to fractional-order methods.