Through an interpretive comparison of five contexts, the book provides an overview of the European orientation tracing two interdependent developments. First, the book examines references to ‘Europe’ in national and subnational policies. In French and German policies, metropolitan regions are increasingly framed as being central not only for inter-municipal coordination, but also as nodes within the European space. Moreover, Europeanised metropolitan regions such as Lyon and Stuttgart develop European strategies. The second development shows how metropolitan regions appear as actors and issues in the European policy arena, contributing to a tentative and implicit metropolitan dimension.