{"product_id":"9783030203030","title":"Advances in Experimental Medicine and Biology: Challenges and Progress","description":"\u003ch1\u003eAdvances in Experimental Medicine and Biology: Challenges and Progress\u003c\/h1\u003e \u003ch2\u003eAhmad, Aamir\u003c\/h2\u003e \u003cp\u003e\u003c\/p\u003e\u003cp\u003eResistance to therapies, both targeted and systemic, and metastases to distant organs are the underlying causes of breast cancer-associated mortality. The second edition of \u003ci\u003eBreast Cancer Metastasis and Drug Resistance\u003c\/i\u003e brings together some of the leading experts to comprehensively understand breast cancer: the factors that make it lethal, and current research and clinical progress. This volume covers the following core topics: basic understanding of breast cancer (statistics, epidemiology, racial disparity and heterogeneity), metastasis and drug resistance (bone metastasis, trastuzumab resistance, tamoxifen resistance and novel therapeutic targets, including non-coding RNAs, inflammatory cytokines, cancer stem cells, ubiquitin ligases, tumor microenvironment and signaling pathways such as TRAIL, JAK-STAT and mTOR) and recent developments in the field (epigenetic regulation, microRNAs-mediated regulation, novel therapies and the clinically relevant 3D models). Expertsalso discuss the advances in laboratory research along with their translational and clinical implications with an overarching goal to improve the diagnosis and prognosis, particularly that of breast cancer patients with advanced disease.\u003cbr\u003e\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e \u003ch3\u003eDetails\u003c\/h3\u003e \u003cp\u003ePublished by: Springer\u003c\/p\u003e \u003cp\u003ePublication Date: 2020-09-05\u003c\/p\u003e \u003cp\u003eFormat: Paperback\u003c\/p\u003e \u003cp\u003eISBN-13: 9783030203030\u003c\/p\u003e \u003cp\u003eDOI: 10.1007\/978-3-030-20301-6\u003c\/p\u003e \u003cp\u003eDimensions: 235cm x155cm\u003c\/p\u003e \u003cp\u003ePages: 427\u003c\/p\u003e ","brand":"Springer International Publishing","offers":[{"title":"Default Title","offer_id":44398535835788,"sku":"9783030203030","price":143.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0710\/9545\/1788\/files\/9783030203030.jpg?v=1777375809","url":"https:\/\/lateknightbooks.com\/products\/9783030203030","provider":"Late Knight Books and Services, LLC","version":"1.0","type":"link"}