{"product_id":"9783030220044","title":"Handbook of Experimental Pharmacology","description":"\u003ch1\u003eHandbook of Experimental Pharmacology\u003c\/h1\u003e \u003ch2\u003eFiorucci, Stefano; Distrutti, Eleonora\u003c\/h2\u003e \u003cp\u003eThis book focusses on the latest results related to the field of  bile acids as signaling molecules  and describes how these receptors have become a major pharmacological target. It covers all major areas of research in this field, from genetics, chemistry, in silico modeling, molecular biology to clinical applications, offering a cross-country view of the functional role of bile acids as signaling molecules, virtually acting on all major areas of metabolism. While FXR  and GPBAR1 are essential bile acid sensors that  integrate the \u003ci\u003ede novo\u003c\/i\u003e bile acid synthesis with intestinal microbiota and  liver metabolism, in a broader sense,  BARs  play a pathogenic role in the development of common human alignments  including  liver, intestinal and metabolic disorders, such as steatosis (NAFLD) and steato-hepatitis (NASH), diabetes, obesity and atherosclerosis. \u003c\/p\u003e \u003ch3\u003eDetails\u003c\/h3\u003e \u003cp\u003ePublished by: Springer\u003c\/p\u003e \u003cp\u003ePublication Date: 2019-09-19\u003c\/p\u003e \u003cp\u003eFormat: Hardcover\u003c\/p\u003e \u003cp\u003eISBN-13: 9783030220044\u003c\/p\u003e \u003cp\u003eDOI: 10.1007\/978-3-030-22005-1\u003c\/p\u003e \u003cp\u003eDimensions: 235cm x155cm\u003c\/p\u003e \u003cp\u003ePages: 378\u003c\/p\u003e ","brand":"Springer International Publishing","offers":[{"title":"Default Title","offer_id":45578495525004,"sku":"9783030220044","price":152.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0710\/9545\/1788\/files\/9783030220044.jpg?v=1775735281","url":"https:\/\/lateknightbooks.com\/products\/9783030220044","provider":"Late Knight Books and Services, LLC","version":"1.0","type":"link"}