{"product_id":"9783030734558","title":"Proteoglycans in Stem Cells: From Development to Cancer","description":"\u003ch1\u003eProteoglycans in Stem Cells: From Development to Cancer\u003c\/h1\u003e \u003ch2\u003eGötte, Martin; Forsberg-Nilsson, Karin\u003c\/h2\u003e \u003cp\u003e\u003c\/p\u003e\u003cp\u003eThis book provides a state-of-the-art compendium on the role of proteoglycans and glycosaminoglycans during development and in cancer. It also suggests directions for novel therapeutic and biotechnological applications in stem cell biology. \u003cbr\u003e Proteoglycans and glycosaminoglycans, as part of the extracellular matrix, are multifunctional modulators of growth factor, cytokine, integrin and morphogen signaling, which determine both self-renewal, senescence and\/or differentiation of stem cells during development. Since proteoglycans modulate cell adhesion and migration they are important organizers of the extracellular matrix within the proper stem cell niche. A malfunctioning of proteoglycans and glycosaminoglycans contributes to the cancer stem cell phenotype, which is linked to therapeutic resistance and recurrence in malignant disease. \u003cbr\u003e This book is essential reading for anyone interested in the extracellular matrix and its role in development.\u003c\/p\u003e\u003cp\u003eThe series \u003ci\u003eBiology of Extracellular Matrix\u003c\/i\u003e is published in collaboration with the American Society for Matrix Biology.\u003cbr\u003e\u003c\/p\u003e\u003cp\u003e\u003cbr\u003e\u003c\/p\u003e\u003cbr\u003e\u003cp\u003e\u003c\/p\u003e \u003ch3\u003eDetails\u003c\/h3\u003e \u003cp\u003ePublished by: Springer\u003c\/p\u003e \u003cp\u003ePublication Date: 2022-06-09\u003c\/p\u003e \u003cp\u003eFormat: Paperback\u003c\/p\u003e \u003cp\u003eISBN-13: 9783030734558\u003c\/p\u003e \u003cp\u003eDOI: 10.1007\/978-3-030-73453-4\u003c\/p\u003e \u003cp\u003eDimensions: 235.0cm x155.0cm\u003c\/p\u003e \u003cp\u003ePages: 308.0\u003c\/p\u003e ","brand":"Springer International Publishing","offers":[{"title":"Default Title","offer_id":45382883344524,"sku":"9783030734558","price":179.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0710\/9545\/1788\/files\/9783030734558.jpg?v=1765492298","url":"https:\/\/lateknightbooks.com\/products\/9783030734558","provider":"Late Knight Books and Services, LLC","version":"1.0","type":"link"}