{"product_id":"9783030740450","title":"Advances in Experimental Medicine and Biology: The Continuum of the NGF “Saga”","description":"\u003ch1\u003eAdvances in Experimental Medicine and Biology: The Continuum of the NGF “Saga”\u003c\/h1\u003e \u003ch2\u003eCalzà, Laura; Aloe, Luigi; Giardino, Luciana\u003c\/h2\u003e \u003cp\u003e\u003c\/p\u003e\u003cp\u003eMore than fifty years after its initial discovery by Rita Levi Montalcini and Stanley Cohen and the proposal of the neurotrophic theory, nerve growth factor (NGF) has become the prototype of a family of biologically active molecules called neurotrophic factors (NTFs).\u003c\/p\u003e\u003cp\u003eThis book addresses important advances in NTF research, from basic science to clinical medicine. It focuses mainly on NGF, but also includes individual chapters dealing with the brain-derived neurotrophic factor (BDNF) and ligands of the glial cell line-derived neurotrophic factor (GDNF) family, which have attracted increasing interest in the neuroscience community because of their diverse effects in the normal and diseased brain.\u003c\/p\u003e\u003cp\u003eIn the first part of the book, the authors provide the necessary background for the following chapters and discuss the basic mechanisms and pathways of NGF signal transduction. In the following sections, they then examine the regenerative activity and neuroprotective capacity of NGF during development and in normal and diseased tissues in adulthood and discuss the role of NGF in Alzheimer's disease and nociception. In addition, the role of NGF in processing sensory information and its influence on behavior is further discussed. The book concludes with an overview of the diagnostic and therapeutic potential of NTF in psychiatric disorders and obesity management, as well as a highlight of NGF research in veterinary medicine.\u003c\/p\u003e\u003cp\u003e \u003c\/p\u003eMany of the authors of this volume participated in the Second International Rita Levi-Montalcini Meeting, held in Bologna, Italy, in 2019. The book covers a wide range of important topics in past and current NTF research and will appeal to basic researchers and clinicians alike.\u003cp\u003e\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e \u003ch3\u003eDetails\u003c\/h3\u003e \u003cp\u003ePublished by: Springer\u003c\/p\u003e \u003cp\u003ePublication Date: 2021-08-28\u003c\/p\u003e \u003cp\u003eFormat: Hardcover\u003c\/p\u003e \u003cp\u003eISBN-13: 9783030740450\u003c\/p\u003e \u003cp\u003eDOI: 10.1007\/978-3-030-74046-7\u003c\/p\u003e \u003cp\u003eDimensions: 254cm x178cm\u003c\/p\u003e \u003cp\u003ePages: 307\u003c\/p\u003e ","brand":"Springer International Publishing","offers":[{"title":"Default Title","offer_id":44775387332748,"sku":"9783030740450","price":224.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0710\/9545\/1788\/files\/9783030740450_4b55580d-9d58-4d4a-88d0-0bb27c0568e4.jpg?v=1777376255","url":"https:\/\/lateknightbooks.com\/products\/9783030740450","provider":"Late Knight Books and Services, LLC","version":"1.0","type":"link"}