{"product_id":"9783030805579","title":"Tumor Suppressor Par-4: Role in Cancer and Other Diseases","description":"\u003ch1\u003eTumor Suppressor Par-4: Role in Cancer and Other Diseases\u003c\/h1\u003e \u003ch2\u003eRangnekar, Vivek M.\u003c\/h2\u003e \u003cp\u003ePar-4 is a naturally occurring tumor suppressor. Studies have indicated that overexpression of Par-4 selectively induces apoptosis in cancer cells while leaving normal, health, cells unaffected. Mechanisms contributing to this cancer-selective action of Par-4 have been associated with PKA activation of intracellular Par-4 in cancer cells or GRP78 expression primarily on the surface of cancer cells. On the other hand, endogenous Par-4 sensitizes cells to the action of a broad range of apoptotic inducers acting via the extrinsic and intrinsic pathways. A number of binding partners of Par-4 have been identified and shown to regulate Par-4 function in cancer and other diseases, such as Alzheimer’s and major depression. Recent studies have recognized a number of natural products, dietary supplements, synthetic molecules and FDA-approved drugs that induce the secretion of Par-4 protein to cause apoptosis in primary or metastatic tumors, one of which is in clinical trials. More than 50 different laboratories worldwide are involved in Par-4 based research of this unique protein that has progressed from the bench to clinical trials.\u003c\/p\u003e\u003cp\u003e\u003cbr\u003e\u003c\/p\u003e\n\n\u003cp\u003eThis second, companion volume will provide a comprehensive overview of Par-4’s role in cancer and other diseases. Chapters are written by leading researchers, and will be useful for a broad audience across the scientific community, particularly students and trainees, who are the next generation of scientists and clinicians to participate in new studies and discoveries on Par-4.\u003c\/p\u003e \u003ch3\u003eDetails\u003c\/h3\u003e \u003cp\u003ePublished by: Springer\u003c\/p\u003e \u003cp\u003ePublication Date: 2021-12-21\u003c\/p\u003e \u003cp\u003eFormat: Hardcover\u003c\/p\u003e \u003cp\u003eISBN-13: 9783030805579\u003c\/p\u003e \u003cp\u003eDOI: 10.1007\/978-3-030-80558-6\u003c\/p\u003e \u003cp\u003eDimensions: 279cm x210cm\u003c\/p\u003e \u003cp\u003ePages: 331\u003c\/p\u003e ","brand":"Springer","offers":[{"title":"Default Title","offer_id":44395091067020,"sku":"9783030805579","price":180.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0710\/9545\/1788\/files\/9783030805579.jpg?v=1755368560","url":"https:\/\/lateknightbooks.com\/products\/9783030805579","provider":"Late Knight Books and Services, LLC","version":"1.0","type":"link"}