This two-volume set constitutes the refereed proceedings of the First International Conference International Conference on Application of Big Data, Blockchain, and Internet of Things for Education Informatization. The conference was held in August 2021 and due to COVID-19 pandemic virtually.The 99 revised full papers and 45 short papers have been selected from 503 submissions. The papers describe research fields such as “big data” and “information education”. The aim of the conference is to provide international cooperation and exchange platforms for big data and information education experts, scholars and enterprise developers to share research results, discuss existing problems and challenges, and explore cutting-edge science and technology.