This LNCS 13453 constitutes the thoroughly refereed proceedings of the 48th International Workshop on Graph-Theoretic Concepts in Computer Science, WG 2022.The 32 full papers presented in this volume were carefully reviewed and selected from a total of 96 submissions. The WG 2022 workshop aims to merge theory and practice by demonstrating how concepts from Graph Theory can be applied to various areas in Computer Science, or by extracting new graph theoretic problems from applications.