The 5th international workshop on Machine Learning in Clinical Neuroimaging (MLCN2022) aims to bring together the top researchers in both machine learning and clinical neuroscience as well as tech-savvy clinicians to address two main challenges: 1) development of methodological approaches for analyzing complex and heterogeneous neuroimaging data (machine learning track); and 2) filling the translational gap in applying existing machine learning methods in clinical practices (clinical neuroimaging track).