This volume LNCS 13582 constitutes the papers of the 19^th International Conference on Trust, Privacy and Security in Digital Business, TrustBus 2022, held in August 2022 in Vienna, Austria, as part of the DEXA 2022 conference. The 11 full papers presented were carefully reviewed and selected from 30 submissions regarding advancements in the state of the art and practice of trust and privacy in digital business. The papers are organized in  topical sections: Trust; Privacy; Security; Digital business; GDPR; Authenticity-enhancing technologies; Internet of Things; Intrusion detection; Honeypots; Homomorphic encryption;, and Serious games.