{"product_id":"9783032010230","title":"Organ System Crosstalk in Critical Illness: From Basic Pathophysiology to Clinical Management","description":"\u003ch1\u003eOrgan System Crosstalk in Critical Illness: From Basic Pathophysiology to Clinical Management\u003c\/h1\u003e \u003ch2\u003eBattaglini, Denise; De Rosa, Silvia; Godoy, Daniel Agustin\u003c\/h2\u003e \u003cp\u003e\u003c\/p\u003e\u003cp\u003eThis book describes deleterious inter-organ crosstalk and its mechanistic concepts, underlying the specific clinical aspect and focusing on medical clinical management in critical care.\u003c\/p\u003e\u003cp\u003eHomeostasis and health of multicellular organisms with multiple organs depends on inter-organ communication. Tissue injury in one organ disturbs this homeostasis and can lead to disease in multiple organs, or multi-organ failure. Many routes of inter-organ crosstalk during homeostasis are relatively well known, but inter-organ crosstalk in disease still lacks understanding. Particularly, how tissue injury in one organ can drive injury at remote sites and trigger multi-organ failure with high mortality is poorly understood. Mechanistically, inter-organ crosstalk after tissue injury could involve soluble mediators and their target receptors, cellular mediators, in particular immune cells, as well as newly identified neuro-immune connections.\u003c\/p\u003e\u003cp\u003eThe book - addressed to healthcare providers working in intensive care units - aims to provide a comprehensive synthesis and interpretation of organ crosstalk, with a particular focus on continuing practice gaps and areas with new data, to assist clinicians in making practical, yet evidence-based decisions regarding nutrition management during the different stages of critical illness.\u003c\/p\u003e \u003ch3\u003eDetails\u003c\/h3\u003e \u003cp\u003ePublished by: Springer\u003c\/p\u003e \u003cp\u003ePublication Date: 2025-11-14\u003c\/p\u003e \u003cp\u003eFormat: Hardcover\u003c\/p\u003e \u003cp\u003eISBN-13: 9783032010230\u003c\/p\u003e \u003cp\u003eDOI: 10.1007\/978-3-032-01024-7\u003c\/p\u003e \u003cp\u003eDimensions: 235.0cm x155.0cm\u003c\/p\u003e \u003cp\u003ePages: 494.0\u003c\/p\u003e ","brand":"Springer Nature Switzerland","offers":[{"title":"Default Title","offer_id":44318310989964,"sku":"9783032010230","price":152.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0710\/9545\/1788\/files\/9783032010230.jpg?v=1765606928","url":"https:\/\/lateknightbooks.com\/products\/9783032010230","provider":"Late Knight Books and Services, LLC","version":"1.0","type":"link"}