This book provides a comprehensive guide to the groundbreaking technologies underpinning the Smart and Connected Health (SCH) revolution. It aims to demystify the principles, architectures, applications, challenges, and potentials of AI, GenAI, TinyML, LLMs, IoT, Edge–Fog–Cloud Computing, Blockchain, and Trustworthy Technologies within the healthcare context. The authors present a thorough compilation of SCH-related content, designed to meet the needs of researchers and practitioners in this field. It delves into the essential aspects of designing and engineering an advanced SCH solution, incorporating a cross-layer approach from the device level to edge/fog/cloud and further into analytics/applications/services.