This book constitutes the proceedings of the 38th International Conference on Computer Applications in Industry and Engineering, CAINE 2025, which took place in New Orleans, LA, USA, during October 20–21, 2025.

The 24 full papers included in this book were carefully reviewed and selected from 48 submissions. These papers were organized into the following topical sections: Intelligent Signals & Smart Learning Systems; Cloud Futures, Blockchain Trust & P2P Innovation; Cybersecurity Frontiers & Resilient IoT; AI Horizons - Models, Methods & Applications.