This book constitutes the proceedings of the 26th International Conference on Bioinformatics and Computational Biology, BIOCOMP 2025; the 11th International Conference on Biomedical Engineering and Sciences, BIOENG 2025; and the 11th International Conference on Health Informatics and Medical Systems, HIMS 2025. They were held as part of the 2025 World Congress in Computer Science, Computer Engineering, and Applied Computing, CSCE 2025, which took place in Las Vegas, NV, USA, during July 21-24, 2025.

The BIOCOMP 2025 Conference received a total of 112 submissions, of which 22 papers were accepted. The BIOENG 2025 Conference received 62 submissions, of which 15 papers were accepted. The HIMS 2025 Conference received a total of 197 submissions, of which 41 papers were accepted. This volume includes 38 of the accepted papers from BIOCOMP 2025, BIOENG 2025, and HIMS 2025.

The papers were organized in topical sections as follows: 26th International Conference on Bioinformatics and Computational Biology - BIOCOMP 2025; 11th International Conference on Biomedical Engineering and Sciences - BIOENG 2025; and HIMS 2025: Health Informatics, Data Science, and Tools; HIMS 2025: Health Informatics, Medical Systems, Data Science, and Tools; and Poster Research Papers.