This new edition is a fully updated and comprehensive guide to radiopharmaceutical chemistry. The stunning clinical successes of nuclear imaging and targeted radiotherapy have resulted in rapid growth in the field of radiopharmaceutical chemistry, an essential component of nuclear medicine and radiology. This new edition addresses the latest advancements in the field.

The text is divided into three overarching sections: First Principles, Radiochemistry, and Special Topics. The first is a general overview covering fundamental and broad issues like “The Production of Radionuclides” and “Basics of Radiochemistry”. The second section is the main focus of the book. In this section, each chapter’s author will delve much deeper into the subject matter, covering both well established and state-of-the-art techniques in radiopharmaceutical chemistry. This section will be divided according to radionuclide and will include chapters on radiolabeling methods using all of the common nuclides employed in radiopharmaceuticals, including four chapters on the ubiquitously used fluorine-18 and a “Best of the Rest” chapter to cover emerging radionuclides. A new chapter on 11C - Next Generation Methods has been added to this edition. Finally, the third section of the book is dedicated to special topics with important information for radiochemists, including three new chapters on improving the pharmacokinetics of radiopharmaceuticals, artificial intelligence in radiopharmaceutical chemistry, and automation in radiochemical synthesis.

This is an ideal educational guide for nuclear medicine physicians, radiologists, and radiopharmaceutical chemists, as well as residents and trainees in all of these areas.

Jason S. Lewis, PhD

Memorial Sloan Kettering Cancer Center

New York, NY

USA

A.D. Windhorst, PhD

Amsterdam University Medical Center

Amsterdam

The Netherlands

Brian M. Zeglis, PhD

Hunter College, City University of New York

New York, NY

USA