This volume gathers a selection of substantially expanded and revised contributions from the 33rd International Conference on Information Systems Development (ISD 2025), which captured cutting-edge research and insights under the theme “Empowering the Interdisciplinary Role of ISD in Addressing Contemporary Issues in Digital Transformation: How Data Science and Generative AI Contributes to ISD.” The contributions provide a comprehensive overview of the transformative potential of technology, highlighting the symbiosis between innovative technologies and organizational processes. As such, they explore topics such as digital transformation, data science, machine learning, generative AI, and the integration of cutting-edge technologies, emphasizing the crucial role of information systems in driving digital change. The book offers valuable insights for researchers, practitioners, and students who seek to understand and shape the future of information systems development in our rapidly evolving digital landscape.

Ivan Luković is a Full Professor at the University of Belgrade (Serbia) in the Faculty of Organizational Sciences, where he lectures in several Information Systems courses. His research interests focus on database systems, information systems, software and systems engineering, domain domain-specific modeling, and business intelligence systems.

Boris Delibašić is a Full Professor at the University of Belgrade (Serbia) in the Faculty of Organizational Sciences, where he lectures in Business Intelligence and Business Decision Making. His research interests include data science, data mining algorithm design, data warehousing, and decision support systems.

Dušan Barać is a Full Professor at the University of Belgrade (Serbia) in the Faculty of Organizational Sciences, where he lectures in several courses, particularly in E-business, Internet Technologies, Simulation and Simulation Languages, Internet Marketing, Internet Intelligent Devices, and Mobile Business. His research interests are in E-business, Web and Mobile Development, E-education, IT project management, E-commerce solutions, and IT ecosystems.

Netta Iivari is a Professor for Information Systems at the University of Oulu, Finland. Her long-lasting research interest concerns understanding and strengthening people's participation in shaping and making their digital futures.

Emilio Insfran is an Associate Professor at the Universitat Politècnica de València, Spain. and Director of the Software Engineering and Information Systems Research Group (ISSI). His main research interests include AI for Software Engineering, Intelligent UI and architecture adaptation, Human-AI collaboration in SE, Requirements Engineering, and Model-Driven Engineering.

Michael Lang is an Associate Professor in Business Information Systems at the Cairnes School of Business and Economics, University of Galway, Ireland. His research interests are business systems analysis and design, data analytics, information systems security and privacy, and information systems education.

Henry Linger is an Associate Professor in the Faculty of Information Technology at Monash University in Melbourne, Australia. His research is directed at understanding how work is actually done by examining the pragmatic, conceptual, and cognitive practices of work in order to inform the design of Information Systems artifacts.

Christoph Schneider is an Associate Professor in the Department of Management, Information Systems, and Entrepreneurship at Washington State University. His research focuses on the effects of user interface design on cognition, affect, and behavior, in particular in the context of web-based user interfaces.