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RNA Localization in Eukaryotes and Prokaryotes
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Results and Problems in Cell Differentiation
RNA Localization in Eukaryotes and Prokaryotes
Malgorzata Kloc
Science / Life Sciences / Molecular Biology
This volume provides a comprehensive overview of RNA localization in both eukaryotic and prokaryotic systems.
In eukaryotic organisms (unicellular, multicellular, animals and plants), the localization and transport of messenger RNA (mRNA) and regulatory small RNAs (sRNA) is a driver of subcellular spatiotemporal complexity and an integral mechanism of cell polarization, polarized cell function, cell fate determination, asymmetric cell division and embryonic patterning. In addition, the localization of organelle-associated RNAs in the vicinity of intracellular organelles is critical for their specific needs and functions. Over the years, it has become clear that despite the absence of a nuclear membrane separating the genetic material from the cytoplasm, prokaryotic organisms can also localize RNA to distinct sites within the cell and use various mechanisms for its trafficking and anchoring.
This book covers all aspects of RNA localization, including different types of localized RNAs, their structure, function, mechanisms of intracellular trafficking, anchoring to different compartments, specific intracellular structures for RNA storage and transport, and new methods to study these processes.
Malgorzata Kloc: Prior to completing her postdoctoral training in Canada, Dr. Kloc was a tenured Associate Professor in the Department of Zoology at the University of Warsaw, Poland. She also served as a Research Associate in the Department of Biology at Carleton University in Ottawa, Canada. While completing her postdoctoral training, Dr. Kloc earned the AHFMR Research Award from the University of Calgary and the MRC Biotechnology Training Award from Dalhousie University. She joined the University of Texas M.D. Anderson Cancer Center as a Research Scientist in the Department of Molecular Genetics in 1987, and became an Associate Professor in the Department of Biochemistry and Molecular Biology there in 2006. Dr. Kloc joined the Houston Methodist Research Institute in 2008. Currently, Dr. Kloc is the Weill Cornell Professor of Cell and Molecular Biology at The Houston Methodist Hospital.
| Publication Date: | 14 October 2026 |
| Publisher: | Springer Nature Switzerland |
| Imprint: | Springer |
| ISBN-13: | 9783032338839 |
| Format: | Hardback |